The association of the homocysteine concentrations and vitamin B12 supplementation with the markers of bone turnover in vegetarians

Primarni cilj ovoga rada bio je utvrditi može li se kontroliranim unosom vitamina B12 utjecati na poboljšanje koncentracije serumskog vitamina B12 te posljedično utjecati na snižavanje koncentracije homocisteina (Hcy) i na promjene u koncentracijama biokemijskih biljega koštane pregradnje u vegetarijanaca s početnim koncentracijama Hcy u plazmi >10 μmol/L te nižim početnim koncentracijama vitamin B12 u serumu (10 μmol/L and lower concentration of vitamin B12 (<300 pg/mL). Additionally the objective was to determine and compare the nutritional status and bone quality in vegetarians and omnivorous. The study included 209 patients (85 vegetarian and omnivorous 124), both sexes, aged ≥21 years. In a randomized, double-blind, placebo-controlled part of the study, which lasted for 6 weeks, 30 patients vegetarians were included, both men and women, average age 33.3 ± 8.5 years. It was confirmed that vegetarians have lower concentrations of serum vitamin B12 (p<0.001) and higher concentration of plasma Hcy (p=0.003); lower body mass index (p<0.001); smaller waist circumference (p<0.001), lower body fat (p<0.001), higher concentrations of folate in serum (p