Clinical and laboratory characteristics of influenza in season 2016/2017

Uvod: Influenca je relativno teška akutna bolest dišnog sustava uzrokovana virusima influence. Uzrokuje brojne komplikacije, a one mogu imati smrtni ishod ili zahtijevaju bolničko liječenje. Ciljevi istraživanja: Prikazati kliničke i laboratorijske značajke sezonske influence u bolesnika liječenih u Klinici za infektivne bolesti "Dr. Fran Mihaljević" u Zagrebu u sezoni 2016./2017.. Ustroj studije: Retrospektivna studija Ispitanici i metode: U istraživanje su uključeni bolesnici oba spola u dobi ≥18 godina s laboratorijski potvrđenom dijagnozom influence, liječeni u Klinici za infektivne bolesti "Dr. Fran Mihaljević" u Zagrebu, u razdoblju od prosinca 2016. do ožujka 2017. godine. Iz istraživanja su isključeni bolesnici kojima nisu učinjene hematološke laboratorijske analize. Rezultati: Statističkom obradom podataka određena je učestalost pojedinih podtipova influence i prisutsvo kroničnih bolesti ili stanja koja mogu predstavljati rizik za nastanak komplikacija. Učinjena je usporedba kliničkih simptoma sezonske influence u ispitivanih bolesnika i rezultata laboratorijskih pretraga prema dobi, spolu, danu i tipu influence. Zaključak: Analizom kliničkih i laboratorijskih značajki influence u ispitivanih bolesnika u Hrvatskoj, u sezoni 2016./2017., dokazan je najčešći tip virusa A/H3N2/, 84,5 % oboljelih, prosječne dobi 58,5 godina. Virus A/H1N1/pdm09 izoliran je u 10,7 % oboljelih te se dokazao učestalijim u bolesnika bez kroničnih bolesti dok je A/H3N2/ učestaliji u bolesnika s kroničnim bolestima. Limfopenija je prisutna u bolesnika s A/H1N1/pdm09 i A/H3N2/ virusom, monocitoza se prosječno javlja u svim podtipovima influence, transaminaze umjereno povišene.Introduction: Influenza is a relatively severe acute respiratory disease caused by influenza viruses. It causes numerous complications which may have a mortal outcome or require hospitalization. Aims: To show the clinical and laboratory characteristics of seasonal influenza in patients treated at the University Hospital for Infectious Diseases "Dr. Fran Mihaljević" in Zagreb in the season 2016/2017. Structure of the study: A retrospective study Subjects and Methods: The study involved population in adults (≥18 years of age) with a laboratory confirmed influenza diagnosis, treated at the University Hospital for Infectious Diseases "Dr. Fran Mihaljević" in Zagreb, in the period from December, 2016 to March, 2017. Patients without hematological laboratory analysis have been excluded from the study. Results: Statistical data processing has determined the frequency of individual influenza subtypes and the presence of chronic illnesses or conditions that may pose a risk of complications. A comparison was made between the clinical symptoms of seasonal influenza of the examined patients and the laboratory examination results according to age, gender, day and type of influence. Conclusion: By analyzing the clinical and laboratory characteristics of influenza of the patients in Croatia in the 2016/2017 season, the most prevalent type of virus was A/H3N2/ (84.5 %), with a mean age of 58.5 years. Virus H1N1/pdm09 was isolated in 10.7 % of patients and proved more frequent in patients without a chronic disease while H3N2 was more common in patients with a chronic disease. Lymphopenia is present in patients with H1N1/pdm09 and H3N2 viruses, monocytosis occurs on average in all influenza subtypes and transaminases are moderately elevated