Metabolic syndrome in hemodialysis patients.

Cilj istraţivanja: Glavni cilj ovog istraţivanja bio je utvrditi prevalenciju oboljelih od metaboliĉkog sindroma u bolesnika lijeĉenih hemodijalizom. Nacrt studije: Provedeno je presjeĉno istraţivanje. Ispitanici i metode: Promatrale su se metaboliĉke znaĉajke kod 150 bolesnika lijeĉenih hemodijalizom na Zavodu za nefrologiju KBC-a Osijek. Rezultati: Metaboliĉki sindrom dijagnosticiran je kod 91 (60,7 %) bolesnika. Najzastupljeniji kriteriji za dijagnozu metaboliĉkog sindroma bili su hipertenzija i sniţen HDL kolesterol. Šećernu bolest imalo je 49 (53,8 %) oboljelih od metaboliĉkog sindroma, dok ih je pretilo bilo 29 (31,9 %). Nije uoĉena statistiĉki znaĉajna povezanost izmeĊu metaboliĉkog sindroma i vrijednosti albumina, hemoglobina, feritina, ukupnog kolesterola, LDL kolesterola, ureje, kreatinina, urata, serumskog natrija, kalija, kalcija, fosfata. S obzirom na podjelu bolesnika prema spolu uoĉene su statistiĉki znaĉajne razlike u nekoliko parametara. Šećerna bolest i sniţena vrijednost HDL kolesterola bili su znaĉajno izraţeniji u ţenskog spola(p = 0,045 u oba sluĉaja). Vrijednost ukupnog kolesterola bila je znaĉajno viši kod ţena (p = 0,016). Vrijednosti kreatinina i urata bile su znaĉajno više kod muških bolesnika (p = 0,004; 0,002). Kt/V bio je znaĉajno viših vrijednosti kod ţena nego kod muškaraca (p < 0,001). Zaključak: Provedeno istraţivanje ne pokazuje znaĉajna odstupanja od do sada provedenih istraţivanja u drugim centrima za hemodijalizu. Budući da je utvrĊena visoka prevalencija metaboliĉkog sindroma kod bolesnika ukljuĉenih u ovo istraţivanje, bitno je pratiti i rano uoĉiti metaboliĉke promjene kod bolesnika te zapoĉeti lijeĉenje kako bi se prevenirale za ţivot opasne posljedice. Ključne riječi: hemodijaliza, hipertenzija, Kt / V, metaboliĉki sindrom, pretilostMETABOLIC SYNDROME IN HEMODIALYSIS PATIENTS Objectives: The main objective of this study was to determine the prevalence of hemodialysis patients affected by metabolic syndrome. Study design: This is a cross-sectional study. Participants and methods: This study examined the metabolic features in 150 patients treated with hemodialysis at the Department of Nephrology at University Hospital Center Osijek. Results: Metabolic syndrome was diagnosed in 91 (60.7 %) patients. The most common criteria for diagnosis of metabolic syndrome were hypertension and decreased HDL cholesterol. Diabetes was found in 49 (53.8 %) patients with metabolic syndrome, while 29 (31.9 %) patients suffered from obesity. There was no statistically significant difference between the metabolic syndrome and albumin, hemoglobin, ferritin, total cholesterol, LDL cholesterol, urea, creatinine, urate, serum sodium, potassium, calcium, phosphate. With respect to the division of patients by sex, statistically significant differences were observed in several parameters. Diabetes, and low HDL cholesterol were significantly more pronounced in women (p = 0.045 in both cases). The total cholesterol was significantly higher in women (p = 0.016). Serum creatinine and urate levels were significantly higher in male patients (p = 0.004; 0.002). Kt/V had significantly higher values in female patients (p < 0.001). Conclusion: This study corroborates other conducted studies in other hemodialysis centers. Having identified a high prevalence of metabolic syndrome in patients in this study, it can be concluded that it is important to monitor and identify the metabolic changes in timely manner in order to start the treatment to prevent the life-threatening consequences. Keywords: hemodialysis, hypertension, Kt/V, metabolic syndrome, obesit