Relationship of thrombocytosis and bronchiolitis in children

CILJ ISTRAŽIVANJA: Cilj je ovoga diplomskog rada ispitati učestalost pojave sekundarne trombocitoze kod djece za vrijeme RSV-a bronhiolitisa i bronhiolitisa uzrokovanog drugim uzročnicima. Istražena je i prediktivna vrijednost sekundarne trombocitoze s obzirom na težinu kliničke slike bronhiolitisa i ishod liječenja kod oboljele djece. NACRT STUDIJE: Retrospektivna studija. ISPITANICI I METODE: U istraživanju se koristila medicinska dokumentacija 136 dojenčadi liječenih na Odjelu pedijatrije Opće županijske bolnice (OŽB) Požega od 1. siječnja 2012. do 1. siječnja 2017. godine zbog bronhiolitisa. Demografski podatci i obilježja pacijenata s bronhiolitisom prikupljeni su pregledom medicinske dokumentacije i statistički obrađeni u SPSS for Windows (inačica 16.0, SPSS Inc., Chicago, IL, SAD). REZULTATI: Logističkom regresijom utvrđena je statistički značajna povezanost trajanja hospitalizacije i primjena kisika u terapiji s trombocitozom. Rizik za pojavu trombocitoze povećava se sa svakim danom hospitalizacije za 18,5 %, a primjena kisika u terapiji pridonosi razvoju trombocitoze za 33,1 %. Potreba za hospitalizacijom i razvoj pneumonije ne utječu statistički značajno na razvoj trombocitoze. ZAKLJUČAK: Djeca s bronhiolitisom koja imaju reaktivnu trombocitozu, imaju teži klinički tijek bolesti, što se očituje duljom hospitalizacijom i potrebom za nadoknadom kisika u liječenju.OBJECTIVE: The objective of this study was to investigate the frequency of secondary thrombocytosis in children during RSV bronchiolitis and bronchiolitis caused by some other cause. Predictive value of secondary thrombocytosis in relation with severity of clinical features and the outcome of the treatment in bronchiolitis affected children has also been studied. STUDY DESIGN: Retrospective study. PARTICIPANTS AND METHODS: Medical records of 136 infants treated at Pediatrics department of County General Hospital Požega from January first, 2012 to January first, 2017 were used in this study. Demographic and other patients' features with bronchiolitis were collected from their medical records. The data was statistically examined in SPSS for Windows (version 16.0, SPSS Inc., Chicago, IL, SAD). RESULTS: The statistically significant association between duration of hospitalization and oxygen application in therapy of thrombocytosis was determined with logistic regression. The risk for thrombocytosis was increased with every day of hospitalization by 18,5 %, and for the oxygen application in therapy by 33,1 %. Need for hospitalization and development of pneumonia statistically do not have an influence on the development of thrombocytosis. CONCLUSION: Children with bronchiolitis and thrombocytosis had a more severe course of the disease, which was presented with longer duration of hospitalization and the need for oxygen application in therapy