Association of adiponectin gene polymorphisms with blood pressure in persons with normal kidney function

Adiponektin je protein koji ima antiaterogene, protuupalne i antidijabetičke učinke u organizmu. Smatra se da je njegova koncentracija inverzno povezana s arterijskim tlakom. U ovom radu ispitivali smo utjecaj dvaju polimorfizama, -11377 C>G i -11391 G>A, gena za adiponektin na arterijski tlak u osoba s normalnom bubrežnom funkcijom. Normotoničari i hipertoničari nisu se razlikovali u plazmatskoj koncentraciji adiponektina, a koncentracija adiponektina nije bila korelirana s arterijskim tlakom niti u jednoj skupini ispitanika. Polimorfizmi gena za adiponektin nisu bili povezani niti s arterijskim tlakom niti s hipertenzijom, ali je polimorfizam -11391 G>A bio povezan s inzulinskom rezistencijom na način da je minor alel A bio alel povišenog rizika. U našoj skupini ispitanika polimorfizmi gena za adiponektin nisu bili povezani s arterijskim tlakom, ali potrebne su veće genetičke epidemiološke studije kako bi se ovaj odnos mogao podrobnije razjasniti.Adiponectin is a protein with antiatherogenous, antiinflammatory and antidiabetic effects. It was found in some studies that its plasma concentration is inversely associated with blood pressure. In this thesis we evaluated the association of two common adiponectin gene polymorphisms, -11377 C>G and -11391 G>A, with blood pressure in persons with normal kidney function. Normotensives and hypertensives did not differ in plasma adiponectin concentration and adiponectin concentration was not correlated with blood pressure in the whole group or in different subgroups. Adiponectin gene polymorphisms were not associated with blood pressure or hypertension, but polymorphism -11391 G>A was associated with insulin resistance, with minor alelle A carrying increased risk. In our group of subjects adiponectin gene polymorphisms were not associated with blood pressure but further larger epidemiologic studies are warranted to clarify this relationship completely