Pentadecapeptide BPC 157 and nitric oxide system relation

U ovom preglednom radu pokušali smo sažeti i pojasniti odnos između BPC 157 i NO sustava, tte povezanost sa Moncadovim homeostatskim odgovorom (održanje vaskularnog integriteta i kontrole na trombocitima) NO sustava na ozljedu. Naime BPC 157 osim određenog učinka cijeljenja isto tako utječe na sve događaje koji uslijede nakon gubitka vaskularnog integriteta (ovisno o uvijetima on smanjuje trombozu ili smanjuje krvarenje to jest trombocitopeniju), dok u cijelom nizu različitih modela ozljeda, akutnih ili kroničnih, BPC 157 uvijek poboljšava proces cijeljenja stimulirajući ekspresiju egr-1 i naB2 gena. Hipoteza da se BPC 157 (pritom se konstitutivno stvara u želučanoj sluznici, uz već poznatu važnost NO sintetaze i bazalnog nakupljanja NO-a u istoj sluznici) iskazuje efektivnu kompeticiju sa L-argininom i njegovim analozima, i da je to sve od fiziološkog značaja, ide u prilog blagotvornim učincima BPC 157 i njegovog uzajamnog odnosa sa NO sustavom. Pri tome mislimo na njihovo međudjelovanje u zaštiti želučane sluznice posljedično akutnim i kroničnim alkoholnim lezijama, u pogledu citoprotekcije, regulaciji krvnog tlaka, kroničnom zatajenju srca, plićnoj hipertenziji, aritmijama, smetnji uzrokovanih hipokalemijom i hiperkalemijom te naposljetku u cijeljenju kompleksnih ozljeda kao što su kolokutane i ezofagokutane fistule. Međutim kako se ova sposobnost moduliranja NO sustava može praktično preslikat u kliničke učinke, tek treba ustvrditi.We reviewed stable gastric pentadecapeptide BPC 157-NO-system-relation, its close participation in Moncada's (maintained vascular integrity, platelets control) homeostatic healing response of NO-system to injury. Namely, BPC 157 particular healing effect also affects all events after vascular integrity loss (dependent on circumstances, it reduces either thrombosis or bleeding/thrombocytopenia) and in a series of different injury models, acute and chronic, BPC 157 consistently advances healing after severe injuries in various tissues spontaneously unable to heal; stimulates egr-1 and naB2 genes; exhibits high safety. Hypothesis, that BPC 157 (since formed constitutively in the gastric mucosa, stable in human gastric juice, along with significance of NO-synthase and the basal formation of NO in stomach mucosa, greater than that seen in other tissues) exhibits a general, effective competing both with L-arginine analogues and L-arginine, and that this has some physiologic importance, later, practically supports its beneficial effects illustrating BPC 157 and NO-system mutual relations in gastric mucosa and mucosal protection, following alcohol lesions, in cytoprotection course, NO-generation, and blood pressure regulation; alcohol acute/chronic intoxication, and withdrawal; cardiovascular disturbances, chronic heart failure, pulmonary hypertension, and arrhythmias; disturbances after hypokalemia and hyperkalemia, and potassium-cell membrane dysfunction; and finally, in complex healing failure, proved by the fistulas healing, colocutaneous and esophagocutaneous. However, how this advantage of modulating NO-system, may be practically translated into an enhanced clinical performance remains to be determined