Recent concepts of ovarian cancer

Karcinom jajnika je vodeći uzrok smrti među zloćudnim novotvorinama ženskog spolnog sustava. Usprkos pokušajima razvoja programa probira s ciljem ranog otkrivanja bolesti, kao i novim terapijskim pristupima, mortalitet nije značajno smanjen. Jedan od razloga ovog neuspjeha bio je slabo razumijevanje patogeneze karcinoma jajnika koji je smatran jedinstvenom bolešću. Nove spoznaje pokazuju da je karcinom jajnika vrlo heterogena bolest, koja se na temelju kliničkopatoloških karakteristika te molekularnih i genetičkih promjena može podijeliti u dvije skupine: tip 1 i tip 2 tumori. Ovaj novi model patogeneze karcinoma jajnika danas ima važan klinički i terapijski značajOvarian cancer is the most lethal gynecologic malignancy. Efforts to develop screening methods and new therapeutic approaches to reduce mortality have been unsuccessful. One of the main reasons for this is our lack of knowledge of the origin and pathogenesis of ovarian cancer. This led to the postulate that it is a single disease. Recent studies have shown that ovarian cancer is a heterogeneous disease composed of diverse types of tumors that can be classified based on clinicopathologic and molecular genetic features into two broad groups designated type 1 and type 2. This new model of pathogenesis of ovarian cancer has significant clinical and therapeutic implication