The multilevel comparison of spatial and hierarchical organisations of urban systems over the world highlights some generic and universal properties (rank-size law, center-periphery structure) but also a variety of more specific patterns (in terms of spatial repartition of populations, densities, prices, activities, etc.). The spatial economy and the urban evolutionnary theory both focus on the explanation of the emergence of such patterns, but the simulation models they support classicaly consider one level of spatial organisation only, respectively intra- and inter-urban. Understanding and reconstructing those levels' interdependancies is a crucial issue for long-term sustainable urban planning. This thesis presents a set of models and to...