Comparison of the effect of therapeutic laser and artificial saliva preparation on the stimulation of saliva secretion

Cilj: Glavni cilj istraživanja je ispitati postoji li razlika u količini izlučene sline u pacijenata koji su koristili umjetnu slinu u odnosu na one čije su velike žlijezde slinovnice tretirane niskoenergetskim laserom kroz 10 uzastopnih tretmana, i to neposredno nakon (Qs i Qss 2) ili mjesec dana od završetka terapije (Qs i Qss 3) u odnosu na početno mjerenje (Qs i Qss 1). Materijali i metode: U istraživanju je sudjelovalo 39 ispitanika kojima je sijalometrijom dokazana suhoća usta (Qs˂2.0 ml/5min). Ispitnu skupinu čini 14 ispitanika koji su podvrgnuti terapiji velikih žlijezda slinovnica niskoenergetskim laserom kroz 10 uzastopnih tretmana dok kontrolnu skupinu čini 25 osoba, koje su prema uputama, više puta dnevno kontinuirano koristile preparat umjetne sline (Caphosol otopina). Rezultati: Rezultati ovog istraživanja pokazali su kako je porast količine izlučene nestimulirane sline (Qs) mjeren 10 dana nakon završetka laser terapije u ispitnoj skupini bio nešto manji u odnosu na kontrolnu skupinu koja je svo to vrijeme koristila preparat umjetne sline. Nešto manja razlika zabilježena je u porastu količine izlučene stimulirane sline (Qss), ali također u korist kontrolne skupine. Stariji ispitanici (iznad 70 godina) pokazuju nešto veći porast u Qs-u i Qss-u neposredno nakon završetka laser terapije odnosno 10 dana od početka korištenja umjetne sline, da bi te vrijednosti nakon mjesec dana bilježile pad. Suprotno tome, mlađi ispitanici pokazuju linearni porast u količini izlučene stimulirane i nestimulirane sline kroz vrijeme. Pacijenti koji ne uzimaju lijekove koji utječu na suhoću usta očekivano bilježe veće početne rezultate i dugoročno veći, linearni napredak kroz vrijeme u količini izlučene nestimulirane (Qs) i stimulirane (Qss) sline. Zaključak: Rezultati ovog istraživanja pokazali su kako je porast u količini izlučene nestimulirane i stimulirane sline nakon mjesec dana od završetka laser terapije ipak veći u ispitanika kontrolne skupine koja je svo vrijeme koristila umjetnu slinu prema uputama, nekoliko puta dnevno.Objective: The main aim of this research is to explore if there is a difference in saliva secretion between patients who were using artificial saliva, and those treated with low-level laser on major salivary glandes through ten consecutive treatments, and soon after (Qs and Qss 2) or one month after therapy was over (Qs and Qss 3) in ratio of first measurment (Qs and Qss 1). Materials and methods: The reaserch contained 39 patients, diagnosed with xerostomia using sialometry test (Qs < 2.0 ml/5min). The tested group contained 14 patients who were treated with low-level laser on major salivary glandes, through ten consecutive treatments, while control group contained 25 patients, who were using artificial saliva (Caphosol) several times a day according to manufacturers guide of product instructions. Results: Results of this research indicate that increase of measured quantum of non stimulated saliva (Qs) secretion in time of ten days after laser therapy, in tested group, was slightly lower in rate of control group who was using artificial saliva through all time. Slightly lower difference was observed in increasing of salivation of stimulated saliva (Qss), but also in favour of control group. Older patients (above 70 years) were showing slightly higher Qs and Qss rate soon after laser therapy was over, regarding ten days of using artificial saliva. After one month, measurment of Qs and Qss salivation quantum rate were decreasing. Younger patients (under 70 years) were showing linear increase in quantum of salivation of stimulated and non stimulated saliva through time. Patients who were not using medication, that can cause mouth dryness, expectedly scored better results and long term better linear progression through time, in order of measured quantum salivation of nonstimulated (Qs) and stimulated (Qss) saliva. Conclusion: Results of this research indicate that increase of measured quantum salivation of non stimulated and stimulated saliva, after one month of finished laser therapy, were higher in control group patients who were using artificial saliva the whole time, according to manufacturers guide of product instructions several times a day