IZVJEŠTAVANJE O SPOLU I RASI/ETNICITETU U RANDOMIZIRANIM KONTROLIRANIM POKUSIMA OBJAVLJENIM U NAJBOLJIM ČASOPISIMA IZ PODRUČJA ANESTEZIOLOGIJE

Aim: The aim of this study was to assess reporting of data on sex and race/ethnicity in randomized controlled trials (RCTs) of interventions published in the highest-ranking journals from the field of anesthesiology. Methods: We analyzed RCTs published from 2014 to mid-2017 in the seven journals belonging to the top 25% in the field of Anesthesiology according to the 2016 Journal Impact Factor published by the database Journal Citation Reports. We extracted data regarding terminology for sex/gender, proportion of participants according to the race/gender and race/ethnicity, and results shown for the race/gender and race/ethnicity. Results: Among the analyzed 657 trials, none stratified participants based on sex/gender or race/ethnicity. Proportion of included women and men was very similar. Most of the included participants were white/Caucasian. Less than 10% of analyzed trial reported information about participants’ ethnicity. Sex-related results were reported in 7.9% and race/ethnicity-related results were reported in 0.15% of analyzed trials. Of the 52 trials that reported sex-related results, 20 (38%) described that there was a significant difference between women and men in at least one analyzed outcome; among 8 trials that reported results based on race/ethnicity, 1 (12.5%) trial reported significant difference in at least one analyzed outcome for participants of different race/ethnicity. Less than 5% of analyzed trials addressed sex/gender or race/ethnicity in Discussion. Conclusion: Sex-specific and race/ethnicity aspects are neglected in anesthesiology trials, even though on average these trials included similar number of women and men. Outcomes related to anesthesiology and pain may differ in participants related to sex and race/ethnicity. Therefore, trialists in the field of anesthesiology should invest more effort to plan, conduct and report sex--specific and race/ethnicity results. Predominant inclusion of white participants in anesthesiology trials should be reconsidered.Cilj: Istražiti načine izvještavanja podatka o spolu i rasi/etnicitetu u randomiziranim kontroliranim pokusima objavljenim u najboljim časopisima iz područja anesteziologije. Metode: Analizirani su randomizirani kontrolirani pokusi objavljeni od 2014. do sredine 2017. godine u sedam časopisa koji se nalaze u 25% najboljih časopisa prema čimbeniku odjeka koji objavljuje baza Journal Citation Reports. Izvađeni su podatci koji se tiču izvještavanja podataka o spolu i rasi/etnicitetu. Rezultati: Analizirano je 657 pokusa. Niti jedan nije stratificirao ispitanike po spolu ili rasi/etnicitetu. Udio uključenih žena i muškaraca u prosjeku je bi podjednak. Većina uključenih ispitanika bili su bijelci. Manje od 10% uključenih radova opisalo je informacije o rasi/etnicitetu uključenih ispitanika. Rezultati koji se tiču analiza prema spolu objavljeni su u 7,9%, a rezultati analiza ovisnih o rasi/etnicitetu u 0,15% uključenih pokusa. Među 52 pokusa koja su prikazala podatke ovisno o spolu, 20 (38%) je opisalo značajne razlike u barem jednom ishodu ovisno o spolu, a u 1 (12,5%) od 8 radova koji su prikazali analize ovisno o rasi/etnicitetu prikazane su razlike prema tom aspektu. Manje od 5% analiziranih pokusa spomenulo je spol ili rasu/etnicitet u Diskusiji. Zaključak: Klinički pokusi iz najboljih anestezioloških časopisa zanemaruj aspekte spola i rase/etniciteta. Rezultati se mogu razlikovati ovisno o tome kojeg je spola i rase/etniciteta ispitanik pa je nužno u budućim istraživanjima planirati, provesti i opisati takve rezultate. Također je nužno uložiti više truda u uključivanje osoba različite rase/etniciteta u kliničke pokuse