Clinical and socio medical aspects of alcoholic liver cirrhosis

Cilj rada: Utvrđivanje težine problema alkoholne ciroze jetre, obrada i prikaz kliničkih i sociomedicinskih parametara ove bolesti. Materijali i metode: Tijekom 2014. godine vršeno je retrospektivno, epidemiološko istraživanje na lokalitetu Križine KBC Split, Interna klinika, Klinički odjel gastroenterologija i hepatologija vezano za socioekonomske i kliničke aspekte oboljelih od alkoholne jetrene ciroze u periodu od 2009. - 2012. godine. Na bolničko liječenje primljeno 15 159. Od tog broja 647 pacijenata primljeno je pod dijagnozom jetrene ciroze. Rezultati: Od 459 bolesnika liječenih radi jetrene ciroze, 93,6 % je imalo alkoholnu cirozu, a 6,3 % cirozu druge etiologije. U razdoblju od 2009. do 2012. godine od ukupnog broja liječenih od alkoholne ciroze, bilo je 72,7 % muškaraca te 27,2 % žena. Prosječna starost muškaraca liječenih zbog alkoholne ciroze iznosila je 61,4 a žena 63,7. Najveći postotak oboljelih konzumirao je vino 43 %, 16 % pivo, te 9 % žestoka pića Iz istraživanja kliničkih aspekata alkoholne ciroze isključeno je 85 oboljelih zbog preboljelog hepatitisa B i/ili C, hepatorenalnog sindrom, neoplazme jetre i hemokromatoze. Prikazani laboratorijski nalazi kod oboljelih od alkoholne ciroze jetre pokazuju tipično odstupanje od normalnih vrijednosi, osim trombocita i eritrocita čije su vrijednosti u granicama normale. Prikazana je karakteristična klinička slika u kojoj prevladava ikterus sa 70 %. Letalitet oboljelih od alkoholne ciroze jetre u ovom istraživanju iznosi 21,7 %. Zaključak: Od ukupnog broja bolesnika od jetrene ciroze liječenih na Internom odjelu KBCa Split najveći postotak boluje od ciroze alkoholne etiologije. 80 % oboljelih od alkoholne ciroze jetre liječi se na Odjelu za gastroenterologiju i hepatologiju. Muškarci piju 2,5 puta češće nego žene. Najčešće konzumirano piće oboljelih od alkoholne ciroze jetre na području Splitsko-dalmatinske županije je vino. Učestala pojava komplikacija alkoholne ciroze jetre razlog je višestrukih hospitalizacija ovih bolesnika.Objective: To determine haeviness of the problem of alcoholic liver cirrhosis, to process and display clinical and sociomedical parameters of this disease. Materials and methods: During the 2014 year a retrospectively, epidemiological research at the site Križine, Split University Hospital, Department of Internal Medicine, Clinical Department gastroenterology and hepatology was done, related to socioeconomic and clinical aspects of patients with alcoholic liver cirrhosis in the period of 2009-2012 years. There were 15 159 hospitalizations in total and 647 were liver cirrhosis. Results: 459 patients were treated for liver cirrhosis, and (n 430) 93,6 % of them had alcohol liver cirrhosis, and (n 29) 6,3 % had non-alcoholic cirrhosis. From 430 patients with alcoholic liver cirrhosis, 72,7 % were men, and 27,2 % were woman. Average age for male patients was 61,4, and for female patients 63,7. The gratest percentage of patients with alcoholic liver cirrhosis consumed wine (43 %), beer (16 %) and destilates (9 %). 85 patients were excluded for the clinical reaserch because of hepatitis B and/or C, hepatorenal syndrom, liver cancer and hemocromatosis. Laboratory results showed tipical deviation from normal values, besides platelets and RBC that were in the range of normal. Characteristic and most often clinical simptom was jaundice (70 %). Alcoholic liver cirrhosis mortality in this reaserch was 21,7 %. Conclusion: The greatest percentage of patients treated for liver cirrhosis in the Clinic for Internal Medicine, Clinical Hospital Centre Split (Križine) had alcoholic liver cirrhosis. 80 % of patients were treated in the Department for gastroenterology and hepatology. Male patients drink 2.5 times more than female patients. The most consumed beverage patients was wine. Frequent appearance of alcoholic liver cirrhosis complications was the reason of multiple hospitalization of these patients