The effect of solvent removal techniques on phase transition, physical stability and dissolution of bicalutamide from solid dispersions containing polyvinylpyrrolidone (PVP) as a carrier was investigated. A spray dryer and a rotavapor were applied to obtain binary systems containing either 50% or 66% of the drug. Applied techniques led to the formation of amorphous solid dispersions as confirmed by X-ray powder diffractometry and differential scanning calorimetry. Moreover, solid–solid transition from polymorphic form I to form II was observed for bicalutamide spray dried without a carrier. The presence of intermolecular interactions between the drug and polymer molecules, which provides the stabilization of molecularly disordered bicalutam...
Many drugs are poorly water soluble and this can limit bioavailability. One way of increasing the di...
Amorphization serves as a strategy for the improvement of poor dissolution characteristics of many ...
Formation of solid dispersions is frequently used as an important strategy to improve the dissolutio...
The effect of solvent removal techniques on phase transition, physical stability and dissolution of ...
The formation of solid dispersions with the amorphous drug dispersed in the polymeric matrix improv...
Amorphous dispersions of the Biclotymol antiseptic are obtained in polyvinylpyrrolidone (PVP), for d...
The oral route is a convenient and most often used route of drug administration to patients. Adequat...
peer-reviewedPrevious research has focused on spray dried quaternary mixtures which, due to the addi...
Amorphous solid dispersions are known to improve the oral bioavailability of poorly water-soluble dr...
The dissolution of poorly soluble drug molecules into a polymer matrix is a popular oral drug delive...
In this paper, we investigated the molecular mobility and physical stability of amorphous bicalutami...
Amorphous solid dispersions have been widely applied to improve the oral bioavailability of BCS Clas...
Purpose Solid dispersions (SDs) represent the most common formulation technique used to increase th...
Real-time in situ Raman mapping has been employed to monitor, during dissolution, the crystallizatio...
ABSTRACTIn this study, we examine the relationship between the physical structure and dissolution be...
Many drugs are poorly water soluble and this can limit bioavailability. One way of increasing the di...
Amorphization serves as a strategy for the improvement of poor dissolution characteristics of many ...
Formation of solid dispersions is frequently used as an important strategy to improve the dissolutio...
The effect of solvent removal techniques on phase transition, physical stability and dissolution of ...
The formation of solid dispersions with the amorphous drug dispersed in the polymeric matrix improv...
Amorphous dispersions of the Biclotymol antiseptic are obtained in polyvinylpyrrolidone (PVP), for d...
The oral route is a convenient and most often used route of drug administration to patients. Adequat...
peer-reviewedPrevious research has focused on spray dried quaternary mixtures which, due to the addi...
Amorphous solid dispersions are known to improve the oral bioavailability of poorly water-soluble dr...
The dissolution of poorly soluble drug molecules into a polymer matrix is a popular oral drug delive...
In this paper, we investigated the molecular mobility and physical stability of amorphous bicalutami...
Amorphous solid dispersions have been widely applied to improve the oral bioavailability of BCS Clas...
Purpose Solid dispersions (SDs) represent the most common formulation technique used to increase th...
Real-time in situ Raman mapping has been employed to monitor, during dissolution, the crystallizatio...
ABSTRACTIn this study, we examine the relationship between the physical structure and dissolution be...
Many drugs are poorly water soluble and this can limit bioavailability. One way of increasing the di...
Amorphization serves as a strategy for the improvement of poor dissolution characteristics of many ...
Formation of solid dispersions is frequently used as an important strategy to improve the dissolutio...