rhBMP-2 applied as support of distraction osteogenesis: a split-mouth histological study over nonhuman primates mandibles

Objective: The purpose of this experimental study was to analyze whether the addition of the recombinant human bone morphogenetic protein type 2 (rhBMP2) to a collagen matrix applied on a distraction osteogenesis device would help healing in the middle new formed bone. A histologic split mouth study on Macaca Fascicularis mandibles was performed. Material and methods: A surgical procedure was conducted on 6 Macaca Fascicularis to obtain 12 bilateral mandibular alveolar defects. All the defects were then reconstructed with a mixture of autogenous bovine bone using osteodistraction device. Two groups, with a total of 12 defects were created: The first group (CONTROL) to study just the effect of the distraction osteogenesis device, the second group (TEST) to compare the effect of rhBMP2 over the bone healing. Results: After 3 months histological evaluation of the mandibles revealed, new bone formation in both groups studied. The control group showed a better regeneration in the midollar bone despite test group recorded more cortical bone. Conclusion: The addition of rhBMP2 into the between of the bone fragment divided by the distraction osteogenesis device induced a rapid increase in hard and soft tissue healing. Moreover, a quick cortical bone formation has been obtained where BMP2 have been applied.Objective: The purpose of this experimental study was to analyze whether the addition of the recombinant human bone morphogenetic protein type 2 (rhBMP2) to a collagen matrix applied on a distraction osteogenesis device would help healing in the middle new formed bone. A histologic split mouth study on Macaca Fascicularis mandibles was performed. Material and methods: A surgical procedure was conducted on 6 Macaca Fascicularis to obtain 12 bilateral mandibular alveolar defects. All the defects were then reconstructed with a mixture of autogenous bovine bone using osteodistraction device. Two groups, with a total of 12 defects were created: The first group (CONTROL) to study just the effect of the distraction osteogenesis device, the second group (TEST) to compare the effect of rhBMP2 over the bone healing. Results: After 3 months histological evaluation of the mandibles revealed, new bone formation in both groups studied. The control group showed a better regeneration in the midollar bone despite test group recorded more cortical bone. Conclusion: The addition of rhBMP2 into the between of the bone fragment divided by the distraction osteogenesis device induced a rapid increase in hard and soft tissue healing. Moreover, a quick cortical bone formation has been obtained where BMP2 have been applied