1,2,3-Triazole Bridge as Conformational Constrain in -Hairpin Peptides: Analysis of Hydrogen-Bonded Positions

Conformational constrained β-hairpin peptides are useful tool to modulate protein-protein interactions. A triazole bridge in hydrogen-bonded positions between two antiparallel strands induces a conformational stabilization of the β-hairpin peptide. The entity of the stability of the β-hairpin peptide depends on the length of the bridge