EZH2 is increased in paediatric T-cell acute lymphoblastic leukemia and is a suitable molecular target in combination treatment approaches
- D'ANGELO, Velia
- Iannotta, A
- Ramaglia, M
- Lombardi, A
- Zarone, M. R
- DESIDERIO, Vincenzo
- Affinita, M. C
- Pecoraro, G
- Di Martino, M
- INDOLFI, Paolo
- CASALE, Fiorina
- CARAGLIA, Michele
Publication date
January 2015
DOI Publisher
Springer Science and Business Media LLCAbstract
T-cell Acute Lymphoblastic Leukemia (ALL) represents about 10-15 % of pediatric ALL cases. EZH2, one of the components of Polycomb group proteins (PRC2) complex, catalyzes the trimethylation of histone H3 lysine 27 that is associated with transcriptional repression and tumor development
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