Iron overload as a consequence of red blood cell transfusions in patients with hematological diseases

Preopterećenje željezom česta je i ozbiljna komplikacija višestrukih transfuzija deplazmatiziranih eritrocita koja pridonosi oštećenju organa te utječe na preživljenje bolesnika s hematološkim bolestima. U ruti nskoj praksi koristi se više metoda za procjenu preopterećenja željezom. Liječenje kelatorima željeza preporučuje se kada serumski feriti n premaši 1.000 ug/L i/ili ako je bolesnik primio više od 20 jedinica deplazmati ziranih eritrocita. Učinkoviti kelatori željeza neprocjenjivo su važni u liječenju preopterećenja željezom bolesnika s hematološkim bolesti ma koji zahti jevaju višestruke transfuzije krvi te dokazano smanjuju njihov morbiditet i poboljšavaju kvalitetu života.Iron overload is a very common and serious complicati on of repeated red blood cell transfusions which contributes to organ dysfuncti on and influences survival in patients with hematological diseases. Several methods for measuring ti ssue iron content are used in every-day practice. Iron chelation therapy is recommanded when serum ferriti n levels reach 1000 ug/L and/or in pati ents who have previously received more then 20 units of red blood cell. Effective iron chelators are essenti al in the management of iron overload of hematological patients that require repeted blood transfusions with proved reducti on of morbidity and improvement of their quality of life