Pathophysiology of cancer pain

Bol je neugodno osjetno i emocionalno iskustvo, udruženo s aktualnim ili potencijalnim oštećenjem tkiva ili opisano u uvjetima takvog oštećenja. Karcinomski bol dijeli se u: nociceptivni, neuropatski i inflamatorni. Nociceptivni bol nastaje podraživanjem nociceptora koji predstavljaju periferne receptore za bol. Neuropatski bol nastaje zbog oštećenja perifernog ili središnjeg živčanog sustava, bez istodobnog podražaja nociceptora. Bol je subjektivan osjećaj, stoga dvije osobe mogu različito doživjeti podražaj jednakog intenziteta. Različita percepcija bola objašnjava se različitom aktivacijom analgezijskog sustava koji nadzire provođenje bolnih impulsa u središnji živčani sustav. Cilj ovoga rada je prikazati patofiziološki mehanizam bola kod onkoloških pacijenata.Pain is an unpleasant sensory and emotional experience associated with actual or potential tissue damage or described in terms of such damages. Cancer pain is divided into: nociceptive, neuropathic and inflammatory. Nociceptive pain occurs by irritation of nociceptors that are peripheral pain receptors. Neuropathic pain is caused by damage to the peripheral or central nervous system, without simultaneous stimulation of nociceptors. Pain is a subjective feeling, and consequently two person can experience different stimuli of equal intensity. Different perception of pain is explained by the different activation of analgesic system which monitors conduction of pain impulses in the central nervous system. The objective of this paper is to present the pathophysiological mechanism of pain in cancer patients