The human heat shock protein HtrA1, a member of the HtrA family of serine proteases, is a evolutionarily highly conserved factor which displays a widespread pattern of expression. The yeast two-hybrid technique was employed to identify new cellular proteins physically interacting with HtrA1, and thus potential targets of this serine protease. An enzymatically inactive HtrA1 point mutant, HtrA1-S328A, was generated and used as bait in a yeast two-hybrid system. Fifty-two plasmids were isolated from primary positive yeast clones. Subsequent sequencing and BLAST analysis revealed cDNAs encoding for 13 different proteins. These putative binding partners of HtrA1 appeared to be a) components of extracellular matrix; b) factors related to signal ...
High-temperature requirement serine protease A1 (HTRA1) is one of four known proteases belonging to ...
An in vitro screening method was developed which allows to identify proteinprotein-interactions on p...
The defining features of the widely conserved HtrA (high temperature requirement) family of serine p...
The human heat shock protein HtrA1, a member of the HtrA family of serine proteases, is a evolutiona...
HtrA1 belongs to a family of serine proteases found in organisms ranging from bacteria to humans. Ba...
HtrA1 belongs to a family of serine proteases found in organisms ranging from bacteria to humans. Ba...
The human HtrA family of proteases consists of three members: HtrA1, HtrA2, and HtrA3. In bacteria, ...
The mammalian high temperature requirement A (HtrA) proteins are a family of evolutionarily conserve...
Heat shock factor 1 (HSF1) is the master transcriptional regulator of the heat shock response (HSR),...
Human HtrA1 belongs to a widely conserved family of serine proteases involved in various aspects of ...
HTRA1 is a serine protease of the trypsin family, as discussed below. The scientific data suggests ...
SummaryThe homotrimeric human serine protease HtrA1 is homologous to bacterial HtrA proteases regard...
Mammalian HtrA (high temperature requirement factor A) proteases, comprising 4 multi-domain members ...
Human serine protease HTRA1 plays an important role in a plethora of physiological processes by reco...
Hamartin and tuberin are products of the tumor suppressor genes TSC1 and TSC2, respectively. Mutatio...
High-temperature requirement serine protease A1 (HTRA1) is one of four known proteases belonging to ...
An in vitro screening method was developed which allows to identify proteinprotein-interactions on p...
The defining features of the widely conserved HtrA (high temperature requirement) family of serine p...
The human heat shock protein HtrA1, a member of the HtrA family of serine proteases, is a evolutiona...
HtrA1 belongs to a family of serine proteases found in organisms ranging from bacteria to humans. Ba...
HtrA1 belongs to a family of serine proteases found in organisms ranging from bacteria to humans. Ba...
The human HtrA family of proteases consists of three members: HtrA1, HtrA2, and HtrA3. In bacteria, ...
The mammalian high temperature requirement A (HtrA) proteins are a family of evolutionarily conserve...
Heat shock factor 1 (HSF1) is the master transcriptional regulator of the heat shock response (HSR),...
Human HtrA1 belongs to a widely conserved family of serine proteases involved in various aspects of ...
HTRA1 is a serine protease of the trypsin family, as discussed below. The scientific data suggests ...
SummaryThe homotrimeric human serine protease HtrA1 is homologous to bacterial HtrA proteases regard...
Mammalian HtrA (high temperature requirement factor A) proteases, comprising 4 multi-domain members ...
Human serine protease HTRA1 plays an important role in a plethora of physiological processes by reco...
Hamartin and tuberin are products of the tumor suppressor genes TSC1 and TSC2, respectively. Mutatio...
High-temperature requirement serine protease A1 (HTRA1) is one of four known proteases belonging to ...
An in vitro screening method was developed which allows to identify proteinprotein-interactions on p...
The defining features of the widely conserved HtrA (high temperature requirement) family of serine p...