The evaluation of peptide structures in solution is made feasible by the combined use of two-dimensional NMR in the laboratory (NOESY) and rotating frames (ROESY), and by the use of molecular dynamics calculations. The present paper describes how both the NMR method and molecular dynamics calculations were applied to very rigid synthetic bicyclic peptides that are analogues of natural amatoxins. The NMR theory, which allows the estimate of interatomic distances between interacting nuclei, is briefly discussed. The experimental data were compared with those of known solid-state structures. Three amatoxin analogues have been examined. Of these, one is biologically active (S-deoxo γ[R] OH-Ile3-amaninamide) and its structure in the solid state ...
Considering the importance of structural patterns in regulating protein-protein interactions (PPIs),...
Molecular dynamics (MD) simulations of short peptides in water were performed to establish whether i...
The conformational properties in DMSO of two head-to-tail cyclic analogues of kallidin ([Lys(0)]-bra...
The evaluation of peptide structures in solution is made feasible by the combined use of two-dimensi...
The evaluation of peptide structures in solution is made feasible by the combined use of two-dimensi...
The evaluation of peptide structures in solution is made feasible by the combined use of two-dimensi...
The effect of substitution of l and d amino acids in amatoxin analogues is discussed in this paper. ...
Amatoxin analogues with d and l-Ala substitutions in position 5 have been studied by means of 1- and...
The interaction between alpha-bungarotoxin and linear synthetic peptides, mimotope of the nicotinic ...
[[abstract]]Studies on the solution conformation of the cyclic depsipeptide antibiotic enopeptin A h...
Molecular dynamics (MD) simulations of short peptides in water were performed to establish whether i...
Considering the importance of structural patterns in regulating protein-protein interactions (PPIs),...
Molecular dynamics (MD) simulations of short peptides in water were performed to establish whether i...
The conformational properties in DMSO of two head-to-tail cyclic analogues of kallidin ([Lys(0)]-bra...
The evaluation of peptide structures in solution is made feasible by the combined use of two-dimensi...
The evaluation of peptide structures in solution is made feasible by the combined use of two-dimensi...
The evaluation of peptide structures in solution is made feasible by the combined use of two-dimensi...
The effect of substitution of l and d amino acids in amatoxin analogues is discussed in this paper. ...
Amatoxin analogues with d and l-Ala substitutions in position 5 have been studied by means of 1- and...
The interaction between alpha-bungarotoxin and linear synthetic peptides, mimotope of the nicotinic ...
[[abstract]]Studies on the solution conformation of the cyclic depsipeptide antibiotic enopeptin A h...
Molecular dynamics (MD) simulations of short peptides in water were performed to establish whether i...
Considering the importance of structural patterns in regulating protein-protein interactions (PPIs),...
Molecular dynamics (MD) simulations of short peptides in water were performed to establish whether i...
The conformational properties in DMSO of two head-to-tail cyclic analogues of kallidin ([Lys(0)]-bra...