Background Hyperhomocysteinaemia occurs in several genetically determined and acquired disorders and is highly prevalent in patients with uraemia. In these disorders, homocysteine precursor S-adenosylhomocysteine, a powerful competitive inhibitor of S-adenosylmethionine-dependent methyltransferases, is increased, suggesting unbalanced methylation. We aimed to investigate whether DNA hypomethylation is present in patients with uraemia who also have hyperhomocysteinaemia and whether regulation of specific classes of genes, dependent on DNA methylation, is compromised.Methods We selected men with hyperhomocysteinaemia and uraemia who were having standard haemodialysis treatment, and compared them with healthy male controls. We measured the hom...
A global loss of cytosine methylation in DNA has been implicated in a wide range of diseases. There ...
Hyperhomocysteinaemia almost invariably occurs in patients with end-stage renal disease (ESRD), but ...
Hyperhomocysteinaemia almost invariably occurs in patients with end-stage renal disease (ESRD), but ...
Aim of this article is to review the topic of epigenetic control of gene expression, especially rega...
Aim of this article is to review the topic of epigenetic control of gene expression, especially rega...
Hyperhomocysteinemia is present in the majority of well-nourished chronic renal failure and uremic p...
Hyperhomocysteinemia is an independent cardiovascular risk factor, according to most observational s...
Hyperhomocysteinemia is an independent cardiovascular risk factor, according to most observational s...
Plasma homocysteine, a well-recognized risk factor for cardiovascular disease, is elevated in uremic...
Plasma homocysteine, a well-recognized risk factor for cardiovascular disease, is elevated in uremic...
Homocysteine (Hcy) is a sulfur-containing non-protein forming amino acid, which is synthesized from ...
Homocysteine (Hcy) is a sulfur-containing non-protein forming amino acid, which is synthesized from ...
Homocysteine (Hcy) is a sulfur-containing non-protein forming amino acid, which is synthesized from ...
Homocysteine (Hcy) is a sulfur-containing non-protein forming amino acid, which is synthesized from ...
Hyperhomocysteinaemia almost invariably occurs in patients with end-stage renal disease (ESRD), but ...
A global loss of cytosine methylation in DNA has been implicated in a wide range of diseases. There ...
Hyperhomocysteinaemia almost invariably occurs in patients with end-stage renal disease (ESRD), but ...
Hyperhomocysteinaemia almost invariably occurs in patients with end-stage renal disease (ESRD), but ...
Aim of this article is to review the topic of epigenetic control of gene expression, especially rega...
Aim of this article is to review the topic of epigenetic control of gene expression, especially rega...
Hyperhomocysteinemia is present in the majority of well-nourished chronic renal failure and uremic p...
Hyperhomocysteinemia is an independent cardiovascular risk factor, according to most observational s...
Hyperhomocysteinemia is an independent cardiovascular risk factor, according to most observational s...
Plasma homocysteine, a well-recognized risk factor for cardiovascular disease, is elevated in uremic...
Plasma homocysteine, a well-recognized risk factor for cardiovascular disease, is elevated in uremic...
Homocysteine (Hcy) is a sulfur-containing non-protein forming amino acid, which is synthesized from ...
Homocysteine (Hcy) is a sulfur-containing non-protein forming amino acid, which is synthesized from ...
Homocysteine (Hcy) is a sulfur-containing non-protein forming amino acid, which is synthesized from ...
Homocysteine (Hcy) is a sulfur-containing non-protein forming amino acid, which is synthesized from ...
Hyperhomocysteinaemia almost invariably occurs in patients with end-stage renal disease (ESRD), but ...
A global loss of cytosine methylation in DNA has been implicated in a wide range of diseases. There ...
Hyperhomocysteinaemia almost invariably occurs in patients with end-stage renal disease (ESRD), but ...
Hyperhomocysteinaemia almost invariably occurs in patients with end-stage renal disease (ESRD), but ...