H19 and Igf2 are linked and reciprocally imprinted genes. We demonstrate that the histones associated with the paternally inherited and unexpressed H19 allele are less acetylated than those associated with the maternal expressed allele. Cell growth in the presence of inhibitors of either histone deacetylase or DNA methylation activated the silent Igf2 allele, whereas derepression of the silent HI9 allele required combined inhibition of DNA methylation and histone deacetylation. Our results indicate that histone acetylation as well as DNA methylation contribute to the somatic maintenance of H19 and Igf2 imprinting and that silencing of the imprinted alleles of these two genes is maintained via distinct mechanisms. Copyright (C) 1999 Federati...
Methylation of CpG dinucleotides is correlated with transcriptional repression of genes, including i...
AbstractExpression of coregulated imprinted genes, H19 and Igf2, is monoallelic and parent-of-origin...
In different eukaryotic model systems, chromatin and gene expression are modulated by post-translati...
H19 and Igf2 are linked and reciprocally imprinted genes. We demonstrate that the histones associate...
AbstractH19 and Igf2 are linked and reciprocally imprinted genes. We demonstrate that the histones a...
AbstractDNA methylation and histone H4 acetylation play a role in gene regulation by modulating the ...
The mouse Igft and H19 genes lie 70-kb apart on chromosome 7 and are reciprocally imprinted. Two reg...
Genomic imprinting marks a subset of autosomal loci expressed in parent of origin-dependent monoalle...
The coordinated regulation of gene expression must be tightly controlled for normal development to o...
Epigenetic is a phenomenon in the process of genomic imprinting called parentof-origin-specific is p...
Genomic imprinting in mammals marks the parental alleles in gametes, resulting in differential gene ...
Mammalian development requires the genomes from the maternal and the paternal side (McGrath and Solt...
Imprinted gene expression corresponds to parental allele-specific DNA CpG methylation and chromatin ...
Igf2 and H19 are physically linked imprinted genes. In embryonic liver, their reciprocal expression ...
An overall coordination between the expressions of genes is required for the proper development of a...
Methylation of CpG dinucleotides is correlated with transcriptional repression of genes, including i...
AbstractExpression of coregulated imprinted genes, H19 and Igf2, is monoallelic and parent-of-origin...
In different eukaryotic model systems, chromatin and gene expression are modulated by post-translati...
H19 and Igf2 are linked and reciprocally imprinted genes. We demonstrate that the histones associate...
AbstractH19 and Igf2 are linked and reciprocally imprinted genes. We demonstrate that the histones a...
AbstractDNA methylation and histone H4 acetylation play a role in gene regulation by modulating the ...
The mouse Igft and H19 genes lie 70-kb apart on chromosome 7 and are reciprocally imprinted. Two reg...
Genomic imprinting marks a subset of autosomal loci expressed in parent of origin-dependent monoalle...
The coordinated regulation of gene expression must be tightly controlled for normal development to o...
Epigenetic is a phenomenon in the process of genomic imprinting called parentof-origin-specific is p...
Genomic imprinting in mammals marks the parental alleles in gametes, resulting in differential gene ...
Mammalian development requires the genomes from the maternal and the paternal side (McGrath and Solt...
Imprinted gene expression corresponds to parental allele-specific DNA CpG methylation and chromatin ...
Igf2 and H19 are physically linked imprinted genes. In embryonic liver, their reciprocal expression ...
An overall coordination between the expressions of genes is required for the proper development of a...
Methylation of CpG dinucleotides is correlated with transcriptional repression of genes, including i...
AbstractExpression of coregulated imprinted genes, H19 and Igf2, is monoallelic and parent-of-origin...
In different eukaryotic model systems, chromatin and gene expression are modulated by post-translati...