Processing and Formulation of Concentrated Protein Solutions - Strategies for their Characterization and Stabilization

Biopharmaceutics are used for therapy of human diseases. Requiring high purity, their downstream process consists of several orthogonal process steps to remove contaminants. Due to increasing product concentrations, these process units are increasingly confronted to cope with concentrated protein solutions. This work describes strategies to characterize protein interactions, aggregation, and dynamic viscosity of concentrated protein solutions in order to improve their processing and formulation