Modification of Bacillus intermedius ribonuclease by urea derivatives

The results of the 'Bacillus intermedius' RNAase modification by urea derivatives are presented. The modifiers synthesized for that purpose were the following: N-(4-chlorbenzoyl)-N'-benzolsulfonyl urea (M 1) and N-(4-chlorbenzoyl)carbomoyl-ε-aminocapronic acid (M 2). It was shown that RNAase modified by M 2 stimulated the cell general metabolism by the test of the cell absorption of neutral red and had a more marked ability to disrupt RNA of the cell plasmatic membranes in comparison to that of the native enzyme