Dipyridamole, an antiplatelet drug used for the secondary prevention and treatment of stroke, also has antiplasmodial activity and enhances the activity of chloroquine. We evaluated the inhibitory effects of dipyridamole on the growths of Babesia and Theileria parasites. The growth of B. bovis and T. equi was significantly inhibited at a 25 μM concentration of dipyridamole, while B. bigemina and B. caballi were significantly inhibited at 50 μM and 1 μM concentrations of dipyridamole, respectively, on day 3 of cultivation. The half maximal inhibitory concentration (IC50) of dipyridamole was calculated at 39.5±4.5, 26.3±10.9, 13.2±3.6, and 23.5±0.5 μM on the growth of B. bovis, B. bigemina, B. caballi, and T. equi, respectively. In a viabilit...
We evaluated the inhibitory effects of pepstatin A and mefloquine on the in vitro and in vivo growth...
Heat shock protein 90 (Hsp90) is a chaperone protein that stabilizes cells during stress or non-stre...
BackgroundChemotherapy is a principle tool for the control and prevention of piroplasmosis. The sear...
Dipyridamole, an antiplatelet drug used for the secondary prevention and treatment of stroke, also h...
Babesia bovis, Babesia bigemina and Theileria equi are worldwide tick-borne hemoprotozoan that cause...
Background:Treatment is the principle way to control and eliminate piroplasmosis. The search for new...
Methylene blue, the first fully synthetic drug, has been widely used in medical treatments. A few de...
The in vitro inhibitory effect of fosmidomycin was evaluated against the asexual growth of bovine Ba...
Evaluation of novel and effective chemotherapeutic agents for bovine and equine piroplasmosis is urg...
The problems of parasite resistance, as well as the toxic residues to most of the commercially avail...
Babesiosis (piroplasmosis) is a transmissible parasitic disease, accompanied by fever, anemia, yello...
Abstract Background Developing new antibabesial drugs with a low toxic effect to the animal and with...
BackgroundChemotherapy is a principle tool for the control and prevention of piroplasmosis. The sear...
Bovine babesiosis, caused by Babesia bovis, is a global tick borne hemoprotozoan parasite disease ch...
Not AvailableThe in vitro growth inhibitory efficacies of five drug molecules against Theileria equi...
We evaluated the inhibitory effects of pepstatin A and mefloquine on the in vitro and in vivo growth...
Heat shock protein 90 (Hsp90) is a chaperone protein that stabilizes cells during stress or non-stre...
BackgroundChemotherapy is a principle tool for the control and prevention of piroplasmosis. The sear...
Dipyridamole, an antiplatelet drug used for the secondary prevention and treatment of stroke, also h...
Babesia bovis, Babesia bigemina and Theileria equi are worldwide tick-borne hemoprotozoan that cause...
Background:Treatment is the principle way to control and eliminate piroplasmosis. The search for new...
Methylene blue, the first fully synthetic drug, has been widely used in medical treatments. A few de...
The in vitro inhibitory effect of fosmidomycin was evaluated against the asexual growth of bovine Ba...
Evaluation of novel and effective chemotherapeutic agents for bovine and equine piroplasmosis is urg...
The problems of parasite resistance, as well as the toxic residues to most of the commercially avail...
Babesiosis (piroplasmosis) is a transmissible parasitic disease, accompanied by fever, anemia, yello...
Abstract Background Developing new antibabesial drugs with a low toxic effect to the animal and with...
BackgroundChemotherapy is a principle tool for the control and prevention of piroplasmosis. The sear...
Bovine babesiosis, caused by Babesia bovis, is a global tick borne hemoprotozoan parasite disease ch...
Not AvailableThe in vitro growth inhibitory efficacies of five drug molecules against Theileria equi...
We evaluated the inhibitory effects of pepstatin A and mefloquine on the in vitro and in vivo growth...
Heat shock protein 90 (Hsp90) is a chaperone protein that stabilizes cells during stress or non-stre...
BackgroundChemotherapy is a principle tool for the control and prevention of piroplasmosis. The sear...