The Histopathological Estimation of Bone Marrows of Clot Sections and Bioptic Specimens on Myelodysplastic Syndromes

Histopathological findings of clot sections and bioptic specimens of bone marrows of 69 patients with myelodysplastic syndromes (MDS) were studied, compared with the cases of anemias, acute leukemias, myeloproliferative disorders, bone marrow transplantation and so on. Each subtype of MDS proposed by FAB cooperative groups was not defined only by histological examination. There were a number of cases in which histological findings were not correlated with hematological data, especially with cellularity, count of megakaryocytes and blast percentage. Presence of proliferating immature precursors indicated high risk of progression to overt leukemia and short survival. The author considers that myelofibrosis is a heterogenous entity, and some of acute myelofibrosis is included in MDS. The author also shows schematically the relationships between acute megakaryoblastic leukemias and several myeloproliferative conditions. Histopathological examination of clot sections and bioptic specimens of bone marrows might provide much informations, and is required to diagnose MDS in addition to bone marrow smears