Experimental Study of Implantation of the Motor Nerve in the Denervated Muscle

Renervation of the denervated muscle by implantation of the motor nerve was experimentally investigated with 190 Wister rats in which peroneal or tibial nerve or both were implanted into the denervated anterior tibial muscle. Results. 1) Regenerated end plates in the denervated anterior tibial muscle after implantation of peroneal or tibial or both nerves can be divided into two kinds, the one newly formed which is ectopically located at the site of the nerve implantation and the other originally existed which is located at the center of the muscle in horseshoe arrangement. 2) Supra-maximal electrical stimulation of peroneal or tibial or both nerves, which were kept intact, repaired or implanted in the denervated anterior tibial muscle proved that only one renervated end plate could exist in one functioning muscle fiber in this experimental model. 3) Implantation of two motor nerves into a denervated anterior tibial muscle resulted in better functional recovery than that of single motor nerve