Hypercholesterolemia in Obese Children : Effect of Weight Loss (Problems Associated With Obesity and/or Hyperlipidemia)

We analyed hypercholesterolemia in 20 obese children, 15 males and 5 females, ages ranged from 7 to 17 years old. They had undergone low-calorie dietary cure (1,360～1,660 calorie/day) and exercise therapy for about 6 months. Age matched controls were 25 non-obese children. Mean±2SD of control subjects were revealed total cholesterol (TC) : 152.8±37.0 mg/dl, high density lipoprotein-cholesterol (HDL) : 54.6±17.2 mg/dl, low density lipoprotein-cholesterol (LDL) : 78.4±31.0 mg/dl, AI ; 1.8±0.9, triglyceride (TG) : 47.8±29.5 mg/dl, Apo B: 67.4±17.7 mg/dl, Apo B/Apo A-1 : 0.54±0.17. The elevation of TC value (>M+2SD : >193.6 mg/dl) was seen in 9 obese children (45%) before therapy, and abnormal high levels were pointed out LDL : 75%, AI : 79%, Apo-B: 63%, Apo B/Apo A-1 : 75% cases before admission. After 2 or 3 months of therapy, the levels of TC, LDL, TG, were entered in normal ranges, on the other hand the values of AI, Apo B, Apo B/Apo A-1 were downed in normal area after 6 months