A formal method for the de-N,N-dialkylation of Sommelet-Hauser rearrangement products
- Tayama, Eiji
- Sato, Ryota
- Takedachi, Keisuke
- Iwamoto, Hajime
- Hasegawa, Eietsu
Publication date
June 2012
DOI Publisher
Elsevier BV ISSN
0040-4020 Journal
Tetrahedron Citation count (estimate)
11Abstract
Selective amine de-alkylation enables the conversion of Sommelet–Hauser rearrangement products into 2-aryl-2-bromoacetic acid derivatives. These compounds are valuable synthetic intermediates in the synthesis of α-aryl-α-amino or α-aryl-β-amino acid derivatives. The method presented herein is a formal de-N,N-dialkylation of Sommelet–Hauser rearrangement products
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