Effects in central catecholamine system by nicotine and nicotinic acetylcholine receptor

学位の種類: 博士（医学）. 報告番号: 乙第1155号. 学位記番号: 新大院博（医）乙第1074号. 学位授与年月日: 平成3年6月6日新潟医学会雑誌. 1991, 105(10), 696-706.We observed the efficacy of cigarette smoking on familial juvenile parkinsonian patients, and considered this efficacy to nicotinic action in the CNS. We tried to confirm the nicotinic function in the rat striatum by means of in vivo microdialysis method, and examined the changes of 3H-nicotine bindings of model rats having lesion of unilateral substantianigra following 6-OHDA injection using the method of macroautoradiography. As a result, DOPAC and HVA values following systemic nicotine injection were elevated statistically comparing to the injection of saline, and radioactivities of 3H-nicotine of lesioned side in striatum, accumbens nucleus, olfactory tubercle weree decreaed statistically comparing to that of non-lesioned side. From these results nicotine and nicotinic acetylcholine recepter are supposed to be closely related to the catecholamine system in the CNS.博士（医学）新潟大