Clinical Study on Treatment Outcome of 135 Oral Squamous Cell Carcinomas for Past 14 Years

To evaluate the prognostic factors for treatment outcome of 135 patients with oral squamous cell carcinomas treated between 1985 and 1998 were analyzed. The 5-year survival rate for entire population was 69%. The value for the tongue (N=53) was 76%, which was followed by 70% of mandibular gingiva (N=29), 65% of the floor of the mouth (N=21), 61% of the buccal mucosa (N=12), and 54% of the maxillary gingiva (N=20). In terms of T and N classifications, the 5-year survival rates for T1 (N=28), T2 (N=48), T3 (N=7), and T4 (N=52) were 96%, 78%, 57% and 47%, and N0 (N=72), N1 (N=34), N2 (N=27) were 79%, 64% and 53%, respectively. The corresponding values for StageⅠ(N=27), StageⅡ (N＝27), StageⅢ (N=20), and Stage Ⅳ (N=61) were 96%, 75%, 75% and 52%, respectively. The value also decreases from 84% to 48% with the increase of grade of invasion. Surgically treated patients (N=90) showed the highest 5-Year survival rate (82%). The outcome was poor in patients with advanced tumor and tumors showing diffuse invasion pattern.最近14年間(1985年～1998年)における口腔扁平上皮癌135症例の治療成績について検討を行った｡原発部位別、T分類別、N分類別、臨床病期別および病理組織学的浸潤様式別の5年累積生存率を算出し比較した｡全135症例の5年生存率は69%であった｡発生部位別では舌が(N＝53)76%、下顎歯肉(N=29)が70%、口底(N＝21)が65%、頬粘膜(N=12)が61%、上顎歯肉(N=20)が54%であった｡T分類別ではTl(N＝28)は96%、T2(N＝48)は78%、T3(N＝7)は57%、T4(N＝52)は47%であり、N分類別ではN０(N＝72)が79%、N１(N＝34)が64%、N2(N=27)が53%であった｡臨床病期別では、StageI (N＝27)は96%、StageⅡ (N=27)は75%、StageⅢ (N＝20)は75%、StageⅣ (N=61)は52%であった｡病理組織学的浸潤様式別では、GradeI (N＝58)が84%、GradeⅡ (N＝51）が61%、GradeⅢ (N＝20)が48%であった｡以上の結果から進行症例および、び慢性の浸潤株式を示す症例の治療成績が低かった