Murine IBD Models and Inflammatory Bowel Disease Symposium Immunology and Diseases in the Skin and Mucous Membrane

Inflammatory bowel diseas is consisted of ulcerative colitis (UC) and Crohn's disease (CD). Their pathogenesis remains largely unknown and hence there lacks any fundamental treatment for these diseases. To reveal the etiopathogenesis and to find novel treatment for IBD, many animal models for IBD have been developed so far. We have established a new animal model for IBD, especially UC, using adoptive cell transfer of immunocompetent cells from mice infected with a murine retrovirus that we termed "MAIDS colitis". In additon, to develop a new treatment for IBD, we have analyzed the therapeutic effect of anti-IP-10 antibody treatment on DSS colitis model. In this seminar, I would like to discuss details of the data