皮膚創傷治癒促進に有効なケア開発の基礎: 17βエストラジオール投与方法の選定

金沢大学医薬保健研究域保健学系本研究はEstradiol Benzoate (EB)の創部塗布の皮膚創傷治癒への効果を従来の方法と比較することを目的とした。創塗布群の創面積比はペレット群と比べて創作製後1-14日目まで、皮膚塗布群と比べて1-9日目まで有意に小さかった。創塗布群の好中球数とマクロファージ数はペレット群及び皮膚塗布群と比べて7日目において有意に減少した。また、創塗布群の単位面積当たりの新生血管数と筋線維芽細胞数割合はペレット群及び皮膚塗布群と比べて7日目において有意に高値を示した。以上の結果より、EBの創部塗布は従来の投与方法よりも炎症抑制、創収縮及び血管新生促進の作用を示すことが明らかとなった。The aim of this study was to compare the effects of the topical application of estradiol benzoate (EB) to wounds with the standard treatment methods. The wound area ratios of the topical EB wound treatment group were significantly smaller than those of the subcutaneous E2 pellet group on days 1-14 and the topical E2 skin application group on days 1-9. Significantly lower numbers of neutrophils and macrophages were seen in the topical EB wound treatment group than in the subcutaneous E2 pellet and topical E2 skin application groups on day 7. Moreover, the number of new blood vessels and the ratio of myofibroblasts were significantly higher in the topical EB wound treatment group than in the subcutaneous E2 pellet and topical E2 skin application groups on day 7. These results indicate that the application of EB to wounds significantly reduces the inflammatory response and promotes wound contraction and angiogenesis compared with the other two standard treatment methods.研究課題/領域番号:15H06236, 研究期間(年度):2015-08-28 - 2016-03-3