The chemistry of 1-hydroxyindoles : syntheses of methyl 1-hydroxyindole-3-acetate, N__-b-acetyl-1- hydroxy-tryptamine, (±)- and (S__-)-1- hydroxytryptophan derivatives

Methyl 1-hydroxyindole-3-acetate, (±)-2-acetoamino-3-(10hydroxyindol-3-yl)propanol, N__-b-acetyl-1-hydroxytryptamine, (±)- and (S__-)-(+)-N__-b-acetyl-1-hydroxytryptophan methyl ester, which are needed for inspecting our hypothesis regarding the metabolism of tryptophan, were prepared for the first time. The structural proof of (±)-N__-b-acetyl-1-hydroxytryptophan methyl ester by X-ray crysatllographic analysis is also reported