Although some CETP-lowering SNPs in the CETP gene are variably associated with improved clinical outcomes in patients with coronary artery disease (CAD), three low molecular weight oral CETP inhibitors (torcetrapib, dalcetrapib, and evacetrapib) have not shown any clinical benefits despite remarkable increases in HDL-cholesterol levels ranging 31-138%. Potential causes for that failure are discussed in terms of off-target effects of some inhibitors, potential misleading interpretation of genetic epidemiological surveys in CETP gene, and inadequate alteration in HDL function induced by the inhibitors. Possible modalities of CETP inhibition such as antisense nucleotides and monoclonal antibodies are discussed.A part of the boo
Although the atheroprotective role of HDL cholesterol (HDL-c) is well documented, effective therapeu...
Although the atheroprotective role of HDL cholesterol (HDL-c) is well documented, effective therapeu...
As delineated in this review, cholesteryl ester transfer protein (CETP) contributes to an atherogeni...
Naturally CETP-deficient animals and genetic cholesteryl ester transfer protein (CETP) deficiency ca...
The recent failure of a major inhibitor of the cholesterol ester transfer protein (CETP), in trials ...
There is a strong need to reduce the risk of cardiovascular disease (CVD) beyond the use of statins ...
In almost 30 years since the introduction of HMG-CoA reductase inhibitors (statins), no other class ...
ObjectivesThis study tested whether genetic variation in the CETP gene is consistent with a protecti...
Cholesteryl ester transfer protein (CETP) facilitates exchange of triglycerides and cholesteryl este...
The atheroprotective role of high-density lipoprotein cholesterol (HDL-C) in cardiovascular disease ...
Background-Cholesteryl ester transfer protein (CETP) inhibitors raise high-density lipoprotein (HDL)...
BACKGROUND— Cholesteryl ester transfer protein (CETP) inhibitors raise high-density lipoprotein (HDL...
BACKGROUND: Cholesteryl ester transfer protein (CETP) inhibitors raise high-density lipoprotein (HDL...
Importance: Cholesteryl ester transfer protein inhibition (CETP) has been shown to increase levels o...
Cholesteryl ester transfer protein (CETP) is a liver-synthesized glycoprotein whose main functions a...
Although the atheroprotective role of HDL cholesterol (HDL-c) is well documented, effective therapeu...
Although the atheroprotective role of HDL cholesterol (HDL-c) is well documented, effective therapeu...
As delineated in this review, cholesteryl ester transfer protein (CETP) contributes to an atherogeni...
Naturally CETP-deficient animals and genetic cholesteryl ester transfer protein (CETP) deficiency ca...
The recent failure of a major inhibitor of the cholesterol ester transfer protein (CETP), in trials ...
There is a strong need to reduce the risk of cardiovascular disease (CVD) beyond the use of statins ...
In almost 30 years since the introduction of HMG-CoA reductase inhibitors (statins), no other class ...
ObjectivesThis study tested whether genetic variation in the CETP gene is consistent with a protecti...
Cholesteryl ester transfer protein (CETP) facilitates exchange of triglycerides and cholesteryl este...
The atheroprotective role of high-density lipoprotein cholesterol (HDL-C) in cardiovascular disease ...
Background-Cholesteryl ester transfer protein (CETP) inhibitors raise high-density lipoprotein (HDL)...
BACKGROUND— Cholesteryl ester transfer protein (CETP) inhibitors raise high-density lipoprotein (HDL...
BACKGROUND: Cholesteryl ester transfer protein (CETP) inhibitors raise high-density lipoprotein (HDL...
Importance: Cholesteryl ester transfer protein inhibition (CETP) has been shown to increase levels o...
Cholesteryl ester transfer protein (CETP) is a liver-synthesized glycoprotein whose main functions a...
Although the atheroprotective role of HDL cholesterol (HDL-c) is well documented, effective therapeu...
Although the atheroprotective role of HDL cholesterol (HDL-c) is well documented, effective therapeu...
As delineated in this review, cholesteryl ester transfer protein (CETP) contributes to an atherogeni...