DNA nanopores offer a unique nano-scale foothold at the membrane interface that can help advance the life sciences as biophysical research tools or gate-keepers for drug delivery. Biological applications require sufficient physiological stability and membrane activity for viable biological action. In this report, we determine essential parameters for efficient nanopore folding and membrane binding in biocompatible cell media. The parameters are identified for an archetypal DNA nanopore composed of six interwoven strands carrying cholesterol lipid anchors. Using gel electrophoresis and fluorescence spectroscopy, the nanostructures are found to assemble efficiently in cell media, such as LB and DMEM, and remain structurally stable at physiolo...
AbstractOver the last decade, functionally designed DNA nanostructures applied to lipid membranes pr...
There is an ever increasing demand within biomedicine for more effective control on the nanoscale, s...
The transport of nutrients, xenobiotics, and signaling molecules across biological membranes is esse...
DNA nanopores offer a unique nano-scale foothold at the membrane interface that can help advance the...
DNA nanopores are bio-inspired nanostructures that control molecular transport across lipid bilayer ...
Recently developed DNA-based analogues of membrane proteins have advanced synthetic biology. A funda...
Biological channels control the transport of vital biomolecular cargo across the cellular membrane. ...
For the past two decades, synthetic transmembrane nanopores and nanochannels have become powerful to...
Recent developments in DNA nanotechnology brought rich structural and functional diversity. However,...
Membrane nanopores are key for molecular transport in biology, portable DNA sequencing, label-free s...
Over the last decade, functionally designed DNA nanostructures applied to lipid membranes prompted i...
DNA is more than a carrier of genetic information: It is a highly versatile structural motif for the...
ABSTRACT: DNA nanotechnology excels at rationally designing bottom-up structures that can functional...
Chemistry is in a powerful position to synthetically replicate biomolecular structures. Adding funct...
Inspired by the biological processes of molecular recognition and transportation across membranes, n...
AbstractOver the last decade, functionally designed DNA nanostructures applied to lipid membranes pr...
There is an ever increasing demand within biomedicine for more effective control on the nanoscale, s...
The transport of nutrients, xenobiotics, and signaling molecules across biological membranes is esse...
DNA nanopores offer a unique nano-scale foothold at the membrane interface that can help advance the...
DNA nanopores are bio-inspired nanostructures that control molecular transport across lipid bilayer ...
Recently developed DNA-based analogues of membrane proteins have advanced synthetic biology. A funda...
Biological channels control the transport of vital biomolecular cargo across the cellular membrane. ...
For the past two decades, synthetic transmembrane nanopores and nanochannels have become powerful to...
Recent developments in DNA nanotechnology brought rich structural and functional diversity. However,...
Membrane nanopores are key for molecular transport in biology, portable DNA sequencing, label-free s...
Over the last decade, functionally designed DNA nanostructures applied to lipid membranes prompted i...
DNA is more than a carrier of genetic information: It is a highly versatile structural motif for the...
ABSTRACT: DNA nanotechnology excels at rationally designing bottom-up structures that can functional...
Chemistry is in a powerful position to synthetically replicate biomolecular structures. Adding funct...
Inspired by the biological processes of molecular recognition and transportation across membranes, n...
AbstractOver the last decade, functionally designed DNA nanostructures applied to lipid membranes pr...
There is an ever increasing demand within biomedicine for more effective control on the nanoscale, s...
The transport of nutrients, xenobiotics, and signaling molecules across biological membranes is esse...