Asymmetric aziridine synthesis via aza-Darzens reaction of bromoacylcamphorsultam
- Cantrill, Alex A.
- Hall, Lee D.
- Jarvis, Ashley N.
- Osborn, Helen M.I.
- Raphy, Jenny
- Sweeney, J. B.
DOIAbstract
The aza-Darzens reaction of the chiral enolate derived from bromoacetylcamphorsultam 1 with N-(diphenylphosphinyl)aryl- and tert-butyl-methanimines proceeds in good yield to give cis-N-(diphenylphosphinyl)aziridinylcarbonyl sultams with high de. Monochiral cis-aziridinecarboxylates may be obtained in acceptable yield by hydrolysis of these sultams
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