The biological diversity of ubiquitination resides in the multivalent nature of linkage-specific homotypic and heterotypic ubiquitin (Ub) chains. A recent publication by Yau et al. in Cell describes the development of K11/K48-bispecific antibodies and a physiological role for K11/K48 heterotypic chains in regulation of the cell cycle and clearance of aggregated proteins
The assembly of a specific polymeric ubiquitin chain on a target protein is a key event in the regul...
The assembly of a specific polymeric ubiquitin chain on a target protein is a key event in the regul...
The diverse outcomes of ubiquitination primarily relate to the flexibility of ubiquitin in forming h...
Posttranslational modification with ubiquitin chains controls cell fate in all eukaryotes. Depending...
Summary Proteasome-mediated degradation occurs with proteins principally modified with lysine-48 pol...
SummaryProteasome-mediated degradation occurs with proteins principally modified with lysine-48 poly...
The covalent attachment of ubiquitin to a protein controls a range of cellular processes in eukaryot...
In eukaryotes, post-translational modification (PTMs) creates a proteome diversity that is essential...
Polyubiquitination, the covalent attachment of a chain of ubiquitin to lysine (K) residues on protei...
Ubiquitylation is one of the most abundant and versatile post-translational modifications (PTMs) in ...
Résumé en anglais uniquementFrom the discovery of ubiquitin and its function as signal for proteasom...
Research on ubiquitin (Ub) signaling has focused primarily on homogeneously linked polyUb. Although ...
The dynamics of cellular signaling events are tightly regulated by a diverse set of ubiquitin chains...
Post-translational modification with ubiquitin is required for cell division, differentiation, and s...
The assembly of a specific polymeric ubiquitin chain on a target protein is a key event in the regul...
The assembly of a specific polymeric ubiquitin chain on a target protein is a key event in the regul...
The diverse outcomes of ubiquitination primarily relate to the flexibility of ubiquitin in forming h...
Posttranslational modification with ubiquitin chains controls cell fate in all eukaryotes. Depending...
Summary Proteasome-mediated degradation occurs with proteins principally modified with lysine-48 pol...
SummaryProteasome-mediated degradation occurs with proteins principally modified with lysine-48 poly...
The covalent attachment of ubiquitin to a protein controls a range of cellular processes in eukaryot...
In eukaryotes, post-translational modification (PTMs) creates a proteome diversity that is essential...
Polyubiquitination, the covalent attachment of a chain of ubiquitin to lysine (K) residues on protei...
Ubiquitylation is one of the most abundant and versatile post-translational modifications (PTMs) in ...
Résumé en anglais uniquementFrom the discovery of ubiquitin and its function as signal for proteasom...
Research on ubiquitin (Ub) signaling has focused primarily on homogeneously linked polyUb. Although ...
The dynamics of cellular signaling events are tightly regulated by a diverse set of ubiquitin chains...
Post-translational modification with ubiquitin is required for cell division, differentiation, and s...
The assembly of a specific polymeric ubiquitin chain on a target protein is a key event in the regul...
The assembly of a specific polymeric ubiquitin chain on a target protein is a key event in the regul...
The diverse outcomes of ubiquitination primarily relate to the flexibility of ubiquitin in forming h...
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