Semin Arthritis Rheum

Background/Purpose:To update definitions of multiple joint osteoarthritis (MJOA), and to determine the frequency and impact of MJOA in a community-based cohort.Methods:Following PRISMA guidelines and with the help of a professional research librarian, we performed a systematic review in Medline using the terms osteoarthritis, generalized, polyarticular, multiple joint, and multi-joint among others, to obtain articles related to MJOA. A total of 42 articles were included for data extraction based on multiple criteria including the requirement for a clearly stated definition of OA assessed at more than one body site. We assessed frequency of these definitions in the Johnston County OA Project (JoCo OA) cohort as well as outcomes related to general health and physical function.Results:A total of 6 clearly stated definitions for MJOA were identified. These definitions were integrated with a list of 24 definitions from our previous systematic review and distilled down to produce 10 literature-derived, operationalized MJOA definitions. Based on these definitions, high frequencies of radiographic (4\u201374%) and symptomatic (2\u201352%) MJOA were found in the JoCo OA. Significant detrimental effects were seen on general health and physical function for most definitions.Conclusions:We constructed a list of 10 summary MJOA definitions based in the literature that are frequent and associated with important clinical outcomes. These definitions capture some of the variability of MJOA phenotypes and provide a starting point for future analyses of both existing and newly initiated studies.R01 AR067743/AR/NIAMS NIH HHS/United StatesP60 AR049465/AR/NIAMS NIH HHS/United StatesU01 DP006266/DP/NCCDPHP CDC HHS/United StatesU01DP006266/ACL/ACL HHS/United StatesT35 AG038047/AG/NIA NIH HHS/United States2020-06-01T00:00:00Z30390991PMC64564317736vault:3187