Add to ORKGCharacterization of the epitopes on antigen recognized by monoclonal antibodies (mAb) is useful for the development of therapeutic antibodies, diagnostic tools, and vaccines. Epitope mapping also provides functional information for sequence-based repertoire analysis of antibody response to pathogen infection and/or vaccination. However, development of mapping strategies has lagged behind mAb discovery. We have developed a site-directed mutagenesis approach that can be used in conjunction with bio-layer interferometry (BLI) biosensors to map mAb epitopes. By generating a panel of single point mutants in the recombinant hemagglutinin (HA) and neuraminidase (NA) proteins of influenza A viruses, we have characterized the epitopes of hundreds of...
The high rate of antigenic drift in seasonal influenza viruses necessitates frequent changes in vacc...
The adaptive immune system produces antibodies to specifically target antigens. Identifying and char...
Epitope-based vaccines show great potential in fighting infectious diseases as well as non-communica...
This book: Epitope Mapping covers all the major methods for the identification and definition of epi...
This is a metadata record only. The full text of the book chapter is not available in this repositor...
Influenza viruses continue to cause substantial morbidity and mortality worldwide. Fast gene mutatio...
Monoclonal antibodies (mAbs) have been used successfully both in research and for clinical purposes....
Monoclonal antibodies (mAbs) have been used successfully both in research and for clinical purposes....
Monoclonal antibodies (mAbs) have been used successfully both in research and for clinical purposes....
Here we define the epitopes on HA that are targeted by a group of 9 recombinant monoclonal antibodie...
Monoclonal antibodies (mAbs) have been used successfully both in research and for clinical purposes....
<p>Generation of panels of high affinity monoclonal single domain antibodies (sdAbs or nanobodies) t...
The characterisation of monoclonal antibodies (MAbs) and their epitopes is important prior to their ...
Hemagglutinin (HA), as a major surface antigen of influenza virus, is widely used as a target for pr...
The high rate of antigenic drift in seasonal influenza viruses necessitates frequent changes in vacc...
The high rate of antigenic drift in seasonal influenza viruses necessitates frequent changes in vacc...
The adaptive immune system produces antibodies to specifically target antigens. Identifying and char...
Epitope-based vaccines show great potential in fighting infectious diseases as well as non-communica...
This book: Epitope Mapping covers all the major methods for the identification and definition of epi...
This is a metadata record only. The full text of the book chapter is not available in this repositor...
Influenza viruses continue to cause substantial morbidity and mortality worldwide. Fast gene mutatio...
Monoclonal antibodies (mAbs) have been used successfully both in research and for clinical purposes....
Monoclonal antibodies (mAbs) have been used successfully both in research and for clinical purposes....
Monoclonal antibodies (mAbs) have been used successfully both in research and for clinical purposes....
Here we define the epitopes on HA that are targeted by a group of 9 recombinant monoclonal antibodie...
Monoclonal antibodies (mAbs) have been used successfully both in research and for clinical purposes....
<p>Generation of panels of high affinity monoclonal single domain antibodies (sdAbs or nanobodies) t...
The characterisation of monoclonal antibodies (MAbs) and their epitopes is important prior to their ...
Hemagglutinin (HA), as a major surface antigen of influenza virus, is widely used as a target for pr...
The high rate of antigenic drift in seasonal influenza viruses necessitates frequent changes in vacc...
The high rate of antigenic drift in seasonal influenza viruses necessitates frequent changes in vacc...
The adaptive immune system produces antibodies to specifically target antigens. Identifying and char...
Epitope-based vaccines show great potential in fighting infectious diseases as well as non-communica...