Coupled Imaging with [ 18 F]FBB and [ 18 F]FDG in AD Subjects Show a Selective Association Between Amyloid Burden and Cortical Dysfunction in the Brain

The present study was aimed to investigate the relationships between dysfunction of cortical glucose metabolism as detectable by means of 2-deoxy-2-[18F]fluoro -D-glucose ([18F]FDG) positron emission tomography/x-ray computed tomography (PET/CT) and amyloid burden as detectable by means of 4-(E)-2-[4-(2-2-[2-[18F]fluoroethoxy]ethoxyethoxy)phenyl]vinyl-N-methylaniline (florbetaben; [18F]FBB) in a group of patients affected by Alzheimer's disease (AD)