Add to ORKGThe present invention relates to a crystal of the protein thymidylate synthase (TS), in particular human TS, in the presence of a ligand, methods of crystallization thereof and uses thereof. The invention also relates to the three- dimensional structure of a new binding site located in the dimerization interface region of TS protein and applications thereof in the design and obtainment of new inhibitors with pharmacological activity, in particular antitumour activity
Thymidylate synthase (TS) is a target for antifolate-based chemotherapies of microbial and human dis...
Human thymidylate synthase (hTS) is pivotal for cell survival and proliferation, indeed it provides ...
Copyright © 2014 Anna Dowierciał et al. This is an open access article distributed under the Creativ...
The present invention relates to a crystal of the protein thymidylate synthase (TS), in particular h...
The crystal structure of human thymidylate synthase, a target for anti-cancer drugs, is determined t...
Thymidylate synthase is an attractive target for antiproliferative drug design because of its key ro...
Human thymidylate synthase is a homodimeric enzyme that plays a key role in DNA synthesis and is a t...
Thymidylate synthase (TS) is a well validated target in cancer chemotherapy. Here, a new crystal for...
Thymidylate synthase (TS) is a very interesting target in antiproliferative diseases. Its inhibition...
The crystal structure of mouse thymidylate synthase (mTS) in complex with substrate dUMP and antifol...
To solve the inhibition mechanism of thymidylate synthase (TS) by N4-hydroxy-dCMP (N4-OH-dCMP), crys...
Human thymidylate synthase has been crystallized in the absence of ligands and diffracts beyond 3.0 ...
ABSTRACT: Thymidylate synthase is an attractive target for antiproliferative drug design because of ...
Recent methodologies applied to the drug discovery process, such as genomics and proteomics, have gr...
Human thymidylate synthase is a homodimeric enzyme that plays a key role in DNA synthesis and is a t...
Thymidylate synthase (TS) is a target for antifolate-based chemotherapies of microbial and human dis...
Human thymidylate synthase (hTS) is pivotal for cell survival and proliferation, indeed it provides ...
Copyright © 2014 Anna Dowierciał et al. This is an open access article distributed under the Creativ...
The present invention relates to a crystal of the protein thymidylate synthase (TS), in particular h...
The crystal structure of human thymidylate synthase, a target for anti-cancer drugs, is determined t...
Thymidylate synthase is an attractive target for antiproliferative drug design because of its key ro...
Human thymidylate synthase is a homodimeric enzyme that plays a key role in DNA synthesis and is a t...
Thymidylate synthase (TS) is a well validated target in cancer chemotherapy. Here, a new crystal for...
Thymidylate synthase (TS) is a very interesting target in antiproliferative diseases. Its inhibition...
The crystal structure of mouse thymidylate synthase (mTS) in complex with substrate dUMP and antifol...
To solve the inhibition mechanism of thymidylate synthase (TS) by N4-hydroxy-dCMP (N4-OH-dCMP), crys...
Human thymidylate synthase has been crystallized in the absence of ligands and diffracts beyond 3.0 ...
ABSTRACT: Thymidylate synthase is an attractive target for antiproliferative drug design because of ...
Recent methodologies applied to the drug discovery process, such as genomics and proteomics, have gr...
Human thymidylate synthase is a homodimeric enzyme that plays a key role in DNA synthesis and is a t...
Thymidylate synthase (TS) is a target for antifolate-based chemotherapies of microbial and human dis...
Human thymidylate synthase (hTS) is pivotal for cell survival and proliferation, indeed it provides ...
Copyright © 2014 Anna Dowierciał et al. This is an open access article distributed under the Creativ...