2-(N-METHYL PIPERAZINE)-5-ARYL-6H-1,3,4-THIADIAZINE DIHYDROBROMIDES HAVING ANTIARRHYTHMIC ACTIVITY

Сидорова, Л. П.
Чупахин, О. Н.
Тренин, Д. С.
Мархасин, В. С.
Шкляр, Т. Ф.
Sidorova, L. P.
Chupakhin, O. N.
Trenin, D. S.
Markhasin, V. S.
Shkljar, T. F.

Publication date

January 1996

Abstract

FIELD: pharmaceutical industry. SUBSTANCE: 2-(N-methyl piperazine)-5-(4-bromophenyl)-6H-1,3,4-thiazine dihydrobromide having essential formula C14H19N4SBr3 is prepared at yield 90 %. Its melting point is 254-256 C. 2-(N-methyl piperazine)-5-phenyl-6H-1,3,4-thiazine dihydrobromide having essential formula C14H20N4SBr2 is prepared at yield 81 %. Its melting point is 198-200 C. EFFECT: improves quality of desired product. 1 dwg, 2 tbl.Использование: в синтезе лекарственных веществ. Сущность: продукт-2-(N-метилпиперазин)-5-(4-брофенил)-6Н-1,3,4-тиадиазин дигидробромид, Б. Ф. C1?4H1?9N4SBr3, выход 90%., Т.пл. 254 - 256oС, 2-(N-метилпиперазин)-5-фенил-6Н-1,3,4-тиадиазин дигидробромид, Б.Ф. C1?4H2?0N4SBr2, выход 81%, Т.пл. 198 - 200oС. 1 ил., 2 та...