Palladium(II) complexes with R2edda-derived ligands. Part II. Synthesis, characterization and in vitro antitumoral studies of R2eddip esters and palladium(II) complexes

  • Zmejkovski, Bojana
  • Kaluđerović, Goran N.
  • Gómez-Ruiz, S.
  • Žižak, Željko
  • Steinborn, D.
  • Schmidt, H.
  • Paschke, Reinhard
  • Juranić, Zorica
  • Sabo, Tibor
Publication date
January 2009
Publisher
Elsevier BV
Journal
European Journal of Medicinal Chemistry

Abstract

New R2eddip-type esters (R = cyclopentyl, L3·2HCl 1.5H2O; cyclohexyl, L4·2HCl·H2O) and corresponding palladium(II) complexes, [PdCl2L3] (3) and [PdCl2L4]·H2O (4), as well as [PdCl2L2] (2; L2 diisobutyl ester of eddip) were synthesized and characterized by IR, 1H and 13C NMR spectroscopies and elemental analysis. The crystal structure of L3·2HCl·2CHCl3 was resolved and is given herein. The NMR spectroscopy confirmed the presence of two isomers (from three possible) for each palladium(II) complex. DFT calculations support the formation of two diastereoisomers. In addition, antitumoral investigations were performed and these investigations also included the diisopropyl ester of eddip (L1) and corresponding palladium(II) complex, [PdCl2L1] (1)....

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NMR spectroscopyTopical concept
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esterChemical compound
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H2OBuilding
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NMRDisease
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HeLaInsect
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cyclopentylChemical substance
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