Correla??o da vitamina D com o perfil lip?dico e glic?dico em indiv?duos com s?ndrome metab?lica

Vitamin D, fat-soluble component acts in the development and support of the bone tissue as well as in the maintenance of calcium and phosphorus homeostasis. When present in low amounts in the body there is a deficiency of vitamin D status, which is related to several diseases such as diabetes, obesity and dyslipidemia which are risk factors for cardiovascular diseases and belong to the metabolic syndrome changes appointed metabolic (MetS). Thus, the objective of this work was to study the levels of vitamin D and its correlation with lipid profile and glucose in subjects with MetS in a city of Santa Catarina west. Worked with fifty individuals of MetS group and fifty individuals in the control group (CT), aged between 40 and 70 years, volunteers of both genders, which were previously classified, as groups, for medical professional unit basic health of the city. Blood samples were collected in vacutainer tubes with and without anticoagulant, with dosages of vitamin D levels and serum lipid profile performed while the analysis of carbohydrate profile gave fluoride in plasma. The research was developed case-control with a quantitative approach, where we used T test with probability level of 5% (p <0.05) and Pearson's correlation coefficient by Graphpad Prism? 6.05 software. Among the results, individuals of the MetS group had significantly decreased levels of vitamin D compared to the CT group (p <0.05). Glucose levels were shown to be not significant for p <0.05. Among the lipid profile, total cholesterol and LDL fraction was shown to be significantly increased in the MetS group compared to the CT group (p <0.05). Since the HDL cholesterol and triglycerides were not significant for p <0.05. The Pearson correlations made between vitamin D and the components of glucose and lipid profile were not significant. The study suggests that low levels of vitamin D in individuals with MetS can contribute as a cardiac risk factor in patients with MetS. In addition, there is the influence that vitamin D may suffer during the analysis period, because it presents changes in serum levels when kept sun exposure and enriched diet.A vitamina D, componente lipossol?vel, atua no desenvolvimento e na sustenta??o do tecido ?sseo, bem como na manuten??o da homeostase do c?lcio e do f?sforo. Quando presente em baixas quantidades no organismo ocorre um estado de defici?ncia de vitamina D, que est? relacionada a in?meras doen?as, como o diabetes, a obesidade e a dislipidemia, que s?o fatores de risco para doen?as cardiovasculares e pertencem ao conjunto de altera??es metab?licas nomeado s?ndrome metab?lica (SMet). Sendo assim, o objetivo deste trabalho foi estudar os n?veis de vitamina D e sua correla??o com o perfil lip?dico e glic?dico em indiv?duos com SMet em uma cidade da regi?o oeste catarinense. Trabalhou-se com cinquenta indiv?duos do grupo SMet e cinquenta indiv?duos do grupo controle (CT), na faixa et?ria entre 40 e 70 anos, volunt?rios, de ambos os g?neros, os quais foram classificados previamente, quanto aos grupos, por profissional m?dico da unidade b?sica de sa?de da cidade. As coletas de sangue ocorreram em tubo vacutainer, com e sem anticoagulante, sendo as dosagens dos n?veis de vitamina D e do perfil lip?dico realizadas em soro, enquanto a an?lise do perfil glic?dico deu-se em plasma fluoretado. A pesquisa desenvolvida foi do tipo caso-controle, com abordagem quantitativa, onde utilizou-se teste T com n?vel de probabilidade de 5% (p<0,05) e coeficiente de correla??o de Pearson atrav?s do software Graphpad Prism? 6.05. Dentre os resultados, os indiv?duos do grupo SMet apresentaram n?veis significativamente diminu?dos de vitamina D quando comparados ao grupo CT (p<0,05). Os n?veis de glicose mostraram-se n?o significativos para p<0,05. Dentre o perfil lip?dico, o colesterol total e a fra??o LDL demonstraram-se significativamente aumentados no grupo SMet quando comparado ao grupo CT (p<0,05). J? a fra??o de colesterol HDL e triglicer?deos n?o foram significativos para p