The application of phytosanitary products in the sugar and ethanol industry has usually targeted pest control. With the epidemic rise in orange rust in sugarcane, caused by fungus Puccinia kuehnii, applications of fungicides are now necessary to protect susceptible varieties. However, few studies have focused on the impacts of the application technology, especially regarding the aerial application and its effects on the plant physiology. This study investigated the different forms of application of fungicides in sugarcane variety SP81-3250 and their association with spray deposition, disease control, productivity, and plant physiology. Experimental units received two different applications of fungicides of the chemical groups strobilurin an...