International audienceAberrant loss of oocytes following cancer treatments or genetic mutations leads to premature ovarian insufficiency (POI) associated with endocrine-related disorders in 1% of women. Therefore, understanding the mechanisms governing oocyte death is crucial for the preservation of female fertility. Here, we report the striking reproductive features of a novel mouse model of POI obtained through oocyte-specific inactivation (ocKO) of Omcg1/Zfp830 encoding a nuclear zinc finger protein involved in pre-mRNA processing. Genetic ablation of OMCG1 in early growing oocytes leads to reduced transcription, accumulation of DNA double-strand breaks and subsequent c-Abl/TAp63-dependent oocyte death, thus uncovering the key role of OM...
In females, germ cells are maintained in ovarian structures called primordial follicles. The number ...
The primordial follicle pool is the main source of developing follicles in the ovary. The length of ...
In the mammalian ovary, the dormant primordial follicles are the source of developing follicles and ...
International audienceAberrant loss of oocytes following cancer treatments or genetic mutations lead...
Premature ovarian insufficiency (POI) occurs in 1% of women of reproductive age. The ovarian manifes...
The mechanisms and aetiology underlying the development of premature ovarian insufficiency (POI) are...
Premature ovarian insufficiency (POI) occurs in 1% of reproductive-age women. The ovarian manifestat...
The mechanisms and aetiology underlying the development of premature ovarian insufficiency (POI) are...
The mechanisms and aetiology underlying the development of premature ovarian insufficiency (POI) are...
Altres ajuts: AMM was supported by a PIF fellowship from Universitat Autònoma de Barcelona (B16P0048...
Apoptosis is a form of programmed cell death that plays a critical role in cellular homeostasis and ...
International audienceWhile highly conserved through evolution, the cell cycle has been extensively ...
Premature ovarian failure (POF) affects up to 1.4% of women under the age of 40 yr and less than 30%...
Infertility in women is caused by a depletion of eggs below the threshold for functional ovulation. ...
Multiple labs have reported that mammalian ovaries contain oogonial stem cells (OSCs), which can dif...
In females, germ cells are maintained in ovarian structures called primordial follicles. The number ...
The primordial follicle pool is the main source of developing follicles in the ovary. The length of ...
In the mammalian ovary, the dormant primordial follicles are the source of developing follicles and ...
International audienceAberrant loss of oocytes following cancer treatments or genetic mutations lead...
Premature ovarian insufficiency (POI) occurs in 1% of women of reproductive age. The ovarian manifes...
The mechanisms and aetiology underlying the development of premature ovarian insufficiency (POI) are...
Premature ovarian insufficiency (POI) occurs in 1% of reproductive-age women. The ovarian manifestat...
The mechanisms and aetiology underlying the development of premature ovarian insufficiency (POI) are...
The mechanisms and aetiology underlying the development of premature ovarian insufficiency (POI) are...
Altres ajuts: AMM was supported by a PIF fellowship from Universitat Autònoma de Barcelona (B16P0048...
Apoptosis is a form of programmed cell death that plays a critical role in cellular homeostasis and ...
International audienceWhile highly conserved through evolution, the cell cycle has been extensively ...
Premature ovarian failure (POF) affects up to 1.4% of women under the age of 40 yr and less than 30%...
Infertility in women is caused by a depletion of eggs below the threshold for functional ovulation. ...
Multiple labs have reported that mammalian ovaries contain oogonial stem cells (OSCs), which can dif...
In females, germ cells are maintained in ovarian structures called primordial follicles. The number ...
The primordial follicle pool is the main source of developing follicles in the ovary. The length of ...
In the mammalian ovary, the dormant primordial follicles are the source of developing follicles and ...