Add to ORKG11siRegulated necrosis occurs in pathologies such as cerebral stroke and myocardial infarction, however the underlying mechanisms and its physiological relevance remain unclear. Here, we report a role for p53 in regulating necrosis in Drosophila spermatogenesis. We found that Drosophila p53 is required for the programmed necrosis that occurs spontaneously in mitotic germ cells during spermatogenesis. Prevention of p53-dependent necrosis resulted in testicular hyperplasia, which was reversed by restoring necrosis in spermatogonia. Drosophila spermatogenesis will thus be a useful model to identify inducers of necrosis to treat cancers that are refractory to apoptosis.nonenoneNapoletano, Francesco; Vincent, Stéphane; Yacobi-Sharon, Keren; Gibe...
During early development, apoptosis plays a major role in the ontogeny of the germ line as a means o...
Apoptosis (programmed cell death) is a conserved process in all animals, used to eliminate damaged o...
When a dicentric chromosome breaks in mitosis, the broken ends cannot be repaired by normal mechanis...
11siRegulated necrosis occurs in pathologies such as cerebral stroke and myocardial infarction, howe...
11siRegulated necrosis occurs in pathologies such as cerebral stroke and myocardial infarction, howe...
<div><p>The importance of regulated necrosis in pathologies such as cerebral stroke and myocardial i...
The importance of regulated necrosis in pathologies such as cerebral stroke and myocardial infarctio...
<p>(<b>A</b>-<b>F</b>) Bright field images of testes from adult wild-type (<i>wt; w</i><sup><i>1118<...
p53 family members have been implicated in regulation of genomic integrity and apoptosis in a variet...
<p>p53 protects cells from DNA damage by inducing cell-cycle arrest upon encountering genomic stress...
Previously, it was implicated that p53 plays a role in spermatogenesis. Here we report that p53 knoc...
SummaryBackgroundThe p53 transcription factor directs a transcriptional program that determines whet...
Exposure to genotoxic stress promotes cell cycle arrest and DNA repair or apoptosis. These “life” or...
AbstractThe final stage of spermatid terminal differentiation involves the removal of their bulk cyt...
International audienceThe canonical role of p53 in preserving genome integrity and limiting carcinog...
During early development, apoptosis plays a major role in the ontogeny of the germ line as a means o...
Apoptosis (programmed cell death) is a conserved process in all animals, used to eliminate damaged o...
When a dicentric chromosome breaks in mitosis, the broken ends cannot be repaired by normal mechanis...
11siRegulated necrosis occurs in pathologies such as cerebral stroke and myocardial infarction, howe...
11siRegulated necrosis occurs in pathologies such as cerebral stroke and myocardial infarction, howe...
<div><p>The importance of regulated necrosis in pathologies such as cerebral stroke and myocardial i...
The importance of regulated necrosis in pathologies such as cerebral stroke and myocardial infarctio...
<p>(<b>A</b>-<b>F</b>) Bright field images of testes from adult wild-type (<i>wt; w</i><sup><i>1118<...
p53 family members have been implicated in regulation of genomic integrity and apoptosis in a variet...
<p>p53 protects cells from DNA damage by inducing cell-cycle arrest upon encountering genomic stress...
Previously, it was implicated that p53 plays a role in spermatogenesis. Here we report that p53 knoc...
SummaryBackgroundThe p53 transcription factor directs a transcriptional program that determines whet...
Exposure to genotoxic stress promotes cell cycle arrest and DNA repair or apoptosis. These “life” or...
AbstractThe final stage of spermatid terminal differentiation involves the removal of their bulk cyt...
International audienceThe canonical role of p53 in preserving genome integrity and limiting carcinog...
During early development, apoptosis plays a major role in the ontogeny of the germ line as a means o...
Apoptosis (programmed cell death) is a conserved process in all animals, used to eliminate damaged o...
When a dicentric chromosome breaks in mitosis, the broken ends cannot be repaired by normal mechanis...