New Variations on the Theme of Gold(III) C^N^N Cyclometalated Complexes as Anticancer Agents: Synthesis and Biological Characterization
- Silvia Carboni
- Antonio Zucca
- Sergio Stoccoro
- Laura Maiore
- Massimiliano Arca
- Fabrizio Ortu
- Christian Artner
- Bernhard K. Keppler
- Samuel M. Meier-Menches
- Angela Casini
- Maria Agostina Cinellu
Publication date
January 2018
DOI Publisher
American Chemical Society (ACS) ISSN
0020-1669Abstract
A new series of novel (C∧N∧N) cyclometalated gold(III) complexes have been characterized for their structural and spectroscopic properties. The anticancer activities of the compounds have been studied in vitro, and their reactivity with model biomolecules has been elucidated by mass spectrometry techniques, evidencing an unexpected preference for binding to nucleic acids with respect to proteins and amino acids
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