Defects in innate immunity render breast cancer initiating cells permissive to oncolytic adenovirus
- Ahtiainen, Laura
- Mirantes, Cristina
- Jahkola, Tiina
- Escutenaire, Sophie
- Diaconu, Iulia
- Osterlund, Pamela
- Kanerva, Anna
- Cerullo, Vincenzo
- Hemminki, Akseli
Publication date
January 2010
DOI Publisher
Public Library of Science (PLoS)Abstract
Cancer stem cells/initiating cells (CSC/CIC), are thought to exist as a small population in malignant tissues. They are resistant to conventional cancer treatments and possibly underlie post-treatment relapse. The CIC population can be targeted with capsid modified oncolytic adenoviruses
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