Dystrophin plays an important role in skeletal muscle by linking the cytoskeleton and the extracellular matrix. The amino-terminus of dystrophin binds to actin, while the carboxy-terminus associates with the dystrophin-associated protein (DAP) complex. Mutations resulting in the loss of dystrophin or other members of this complex result in several forms of muscular dystrophy, including Duchenne muscular dystrophy. We have generated transgenic/mdx mice expressing full-length dystrophin constructs with consecutive deletions within the C-terminal domains to analyze the interaction of dystrophin with members of the DAP complex and the effects that perturbing these associations have on the dystrophic process. Deletions within the cysteine rich r...
The dystrophin associated protein (DAP) complex has been implicated in such basic physiological proc...
The dystroglycan complex contains the transmembrane protein β-dystroglycan and its interacting extra...
International audienceDystrophin is essential for muscle health: its sarcolemmal absence causes the ...
Dystrophin is a multidomain protein that forms the core of the dystrophin associated protein (DAP) c...
AbstractDuchenne muscular dystrophy (DMD) patients and mdx mice are characterized by the absence of ...
AbstractDuchenne muscular dystrophy is the most prevalent and severe form of human muscular dystroph...
Dystrophin is a multidomain protein that links the actin cytoskeleton to laminin in the extracellula...
Dystrophin is a multidomain protein that links the actin cytoskeleton to laminin in the extracellula...
AbstractDuchenne muscular dystrophy (DMD) patients and mdx mice are characterized by the absence of ...
An intracellular protein, dystrophin, plays an important role in keeping muscle fibers intact by bin...
An intracellular protein, dystrophin, plays an important role in keeping muscle fibers intact by bin...
Duchenne muscular dystrophy (DMD) is a lethal X-linked recessive muscle wasting disease caused by th...
<div><p>The dystroglycan complex contains the transmembrane protein β-dystroglycan and its interacti...
The dystroglycan complex contains the transmembrane protein β-dystroglycan and its interacting extra...
AbstractBackground: Dystrophin is an essential component of skeletal muscle cells. Its N-terminal do...
The dystrophin associated protein (DAP) complex has been implicated in such basic physiological proc...
The dystroglycan complex contains the transmembrane protein β-dystroglycan and its interacting extra...
International audienceDystrophin is essential for muscle health: its sarcolemmal absence causes the ...
Dystrophin is a multidomain protein that forms the core of the dystrophin associated protein (DAP) c...
AbstractDuchenne muscular dystrophy (DMD) patients and mdx mice are characterized by the absence of ...
AbstractDuchenne muscular dystrophy is the most prevalent and severe form of human muscular dystroph...
Dystrophin is a multidomain protein that links the actin cytoskeleton to laminin in the extracellula...
Dystrophin is a multidomain protein that links the actin cytoskeleton to laminin in the extracellula...
AbstractDuchenne muscular dystrophy (DMD) patients and mdx mice are characterized by the absence of ...
An intracellular protein, dystrophin, plays an important role in keeping muscle fibers intact by bin...
An intracellular protein, dystrophin, plays an important role in keeping muscle fibers intact by bin...
Duchenne muscular dystrophy (DMD) is a lethal X-linked recessive muscle wasting disease caused by th...
<div><p>The dystroglycan complex contains the transmembrane protein β-dystroglycan and its interacti...
The dystroglycan complex contains the transmembrane protein β-dystroglycan and its interacting extra...
AbstractBackground: Dystrophin is an essential component of skeletal muscle cells. Its N-terminal do...
The dystrophin associated protein (DAP) complex has been implicated in such basic physiological proc...
The dystroglycan complex contains the transmembrane protein β-dystroglycan and its interacting extra...
International audienceDystrophin is essential for muscle health: its sarcolemmal absence causes the ...